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Faculty Directory

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TPCB students have unparalleled opportunities to work with over 50 faculty members on diverse research topics in chemical biology at Weill Cornell, Rockefeller, and Sloan Kettering. Our faculty includes a combination of internationally-recognized luminaries and emerging scientific leaders of the future. Our laboratories are well-funded, with over $50 million in NIH research grants and an NIH Chemistry–Biology Interface Training Grant. Our faculty have been recognized with numerous major awards, including the Nobel Prize in Chemistry to Prof. Roderick MacKinnon in 2003 and Breakthrough Prizes in Life Sciences to Prof. Lewis Cantley in 2013 and to Prof. C. David Allis in 2015. We also include seven members of the National Academy of Sciences, two members of the National Academy of Medicine, six Howard Hughes Medical Institute Investigators, one HHMI Faculty Scholar, one HHMI Early Career Scientist, two NCI Outstanding Investigators, two NIGMS MIRA Awardees, seven NIH Director’s New Innovators, and one NIH Pathway to Independence Awardee.

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Faculty Member Institution Research Topics Therapeutic Areas Research Description
faculty photo C. David Allis, PhD2015 Breakthrough Prize in Life Sciences
Member, National Academy of Science
Rockefeller Macromolecular Structure and Function: Enzymology, Chemical Cell Biology Cancer Histone methylation and the histone code
faculty photo Olaf Andersen, MD Weill Cornell Bioactive Small Molecules: High-throughput screening assays, Chemical probe development, Macromolecular Structure and Function: Enzymology, Single molecule methods Immunology, Microbiology, Neuroscience Molecular mechanisms of ion channels
faculty photo Daniel Bachovchin, PhD Sloan Kettering Bioactive Small Molecules: Rational drug design, High-throughput screening assays, Chemical probe development, Macromolecular Structure and Function: Enzymology, Mass spectrometry, Chemical Cell Biology: Proteomics, Activity-based protein profiling Cancer, Immunology, Microbiology Chemical probe discovery and characterization
faculty photo Scott Blanchard, PhD Weill Cornell Bioactive Small Molecules: Total synthesis, High-throughput screening assays, Chemical probe development, Macromolecular Structure and Function: X-ray crystallography, Cryo-electron microscopy, Single molecule methods, Chemical Cell Biology: Cellular imaging, Biotechnology: Protein engineering, Nanotechnology, Computational Chemistry Cancer, Microbiology, Neuroscience, Virology Single-molecule studies protein synthesis
faculty photo John Blenis, PhD Weill Cornell Bioactive Small Molecules: High-throughput screening assays, Chemical Cell Biology: Chemical genetics, Proteomics, Metabolomics Cancer Signal transduction pathways and cancer cell biology
faculty photo Olga Boudker, PhD
HHMI Investigator
Weill Cornell Macromolecular Structure and Function: X-ray crystallography, Biotechnology: Protein engineering Neuroscience Molecular mechanisms of membrane transporters
faculty photo Sean Brady, PhDHHMI Early Career Scientist Rockefeller Bioactive Small Molecules: Natural product biosynthesis, Macromolecular Structure and Function: Enzymology, NMR spectroscopy, Biotechnology Cancer, Microbiology Genetically encoded small molecules
faculty photo Jochen Buck, MD, PhD Weill Cornell Bioactive Small Molecules: Rational drug design, High-throughput screening assays, Macromolecular Structure and Function: Enzymology, Chemical Cell Biology: Proteomics, Metabolomics Cancer, Cardiovascular, Diabetes, Microbiology Biology of soluble adenylyl cyclases
faculty photo Lewis Cantley, PhD2013 Breakthrough Prize in Life Sciences
Member, National Academy of Science
Member, National Academy of Medicine
NCI Outstanding Investigator
Weill Cornell Bioactive Small Molecules: High-throughput screening assays, Macromolecular Structure and Function: Enzymology, Mass spectrometry, Chemical Cell Biology: Proteomics, Metabolomics Cancer, Diabetes Biochemical pathways of cell growth and transformation
faculty photo Brian Chait, DPhil Rockefeller Macromolecular Structure and Function: Mass spectrometry, Chemical Cell Biology: Cellular imaging, Proteomics, Biotechnology: Protein engineering, Nanotechnology, Computational Chemistry: Docking, Protein modeling Cancer, Immunology, Microbiology, Neuroscience, Virology Mass spectrometery and gaseous ion chemistry
faculty photo Jue Chen, PhDHHMI Investigator Rockefeller Macromolecular Structure and Function: X-ray crystallography, Cryo-electron microscopy Cancer, Immunology, Microbiology Structure and regulation of ATP-powered membrane transporters
faculty photo Shuibing Chen, PhDNIH Director’s New Innovator Weill Cornell Bioactive Small Molecules: High-throughput screening assays, Chemical Cell Biology: Chemical genetics Cancer, Cardiovascular, Diabetes Stem cell and chemical biology
faculty photo Gabriela Chiosis, PhD Sloan Kettering Bioactive Small Molecules: Chemical methodology, Rational drug design, High-throughput screening assays, Chemical probe development, Macromolecular Structure and Function: Mass spectrometry, Chemical Cell Biology: Chemical genetics, Cellular imaging, Proteomics, Biotechnology: Radiochemistry, Computational Chemistry: Docking, Protein modeling Cancer, Neuroscience Heat shock proteins – chemical biology and drug discovery
faculty photo John Chodera, PhD Sloan Kettering Bioactive Small Molecules: Rational drug design, High-throughput screening assays, Macromolecular Structure and Function, Biotechnology: Protein engineering, Computational Chemistry: Cheminformatics, Docking, Protein modeling Cancer, Virology Effects of small molecules on biomolecular macromolecules and cellular pathways
faculty photo Samuel Danishefsky, PhDProfessor Emeritus
Member, National Academy of Science
Sloan Kettering Bioactive Small Molecules: Chemical methodology, Total synthesis, Biotechnology: Protein engineering Cancer, Immunology, Microbiology Syntheses of antitumor and anti-infective natural products
faculty photo Seth Darst, PhDMember, National Academy of Science
NIGMS MIRA Awardee
Rockefeller Macromolecular Structure and Function: X-ray crystallography, Computational Chemistry: Protein modeling Microbiology Structural aspects of transcription
faculty photo Yael David, PhD Sloan Kettering Bioactive Small Molecules: Chemical probe development, Macromolecular Structure and Function: Enzymology, Mass spectrometry, Chemical Cell Biology: Chemical genetics, Cellular imaging, Activity-based protein profiling, Biotechnology: Protein engineering Cancer, Diabetes Epigenetic regulation and cancer
faculty photo David Eliezer, PhD Weill Cornell Macromolecular Structure and Function: NMR spectroscopy, Computational Chemistry: Protein modeling Neuroscience Biological role of non-native protein structure
faculty photo Jonathan Goldberg, PhDHHMI Investigator Sloan Kettering Macromolecular Structure and Function: X-ray crystallography, Cryo-electron microscopy Structural studies of vesicle transport and DNA repair
faculty photo Steven Gross, PhD Weill Cornell Bioactive Small Molecules: Chemical methodology, High-throughput screening assays, Chemical probe development, Macromolecular Structure and Function: Mass spectrometry, Chemical Cell Biology: Chemical genetics, Proteomics, Metabolomics Metabolomics, metabolite profiling, stable isotope tracing, pathway analysis
faculty photo Lorraine Gudas, PhD Weill Cornell Bioactive Small Molecules: High-throughput screening assays, Macromolecular Structure and Function: Enzymology, Chemical Cell Biology: Cellular imaging, Metabolomics Cancer, Diabetes Retinoid pharmacology
faculty_photo_hang_howard Howard Hang, PhD Rockefeller Bioactive Small Molecules: Chemical probe development, Chemical Cell Biology: Proteomics Immunology, Microbiology, Virology Development of new chemical tools for studying protein lipidation and glycosylation
faculty photo Daniel Heller, PhDNIH Director’s New Innovator Sloan Kettering Chemical Cell Biology: Cellular imaging, Biotechnology: Nanotechnology Cancer Nanochemistry for molecular sensors and targeted therapeutics
faculty photo Richard Hite, PhD Sloan Kettering Macromolecular structure and function: X-ray crystallography, Cryo-electron microscopy, Single molecule methods Cancer, Neuroscience Structural and functional characterization of ion channels
faculty photo Morgan Huse, PhD Sloan Kettering Bioactive Small Molecules: Chemical probe development, Chemical Cell Biology: Chemical genetics, Cellular imaging Cancer, Immunology Chemical biology of lymphocyte signalling
faculty photo Samie Jaffrey, MD, PhD Weill Cornell Bioactive Small Molecules: High-throughput screening assays, Chemical probe development, Macromolecular Structure and Function: Enzymology, Mass spectrometry, Chemical Cell Biology: Chemical genetics, Cellular imaging, Proteomics, Metabolomics Cancer, Diabetes, Neuroscience Neuronal signal transduction and chemical biology
faculty photo Xuejun Jiang, PhD Sloan Kettering Bioactive Small Molecules: High-throughout screening assays, Chemical proble development, Rational drug design, Macromolecular Structure and Function: Enzymology, Mass spectrometry, Chemical Cell Biology: Chemical genetics, Proteomics, Metabolomics Cancer, Cardiovascular, Neuroscience Cell death and autophagy, mechanisms and drug discovery
faculty photo Tarun Kapoor, PhD Rockefeller Bioactive Small Molecules: Rational drug design, High-throughput screening assays, Chemical probe development, Macromolecular Structure and Function: Enzymology, Mass spectrometry, Single molecule methods, Chemical Cell Biology: Chemical genetics, Cellular imaging, Proteomics Cancer Chemistry and cell biology
faculty photo Alex Kentsis, MD, PhD Sloan Kettering Bioactive Small Molecules: Rational drug design, Macromolecular Structure and Function, Chemical Cell Biology: Proteomics, Biotechnology: Protein engineering, Computational Chemistry Cancer Functional proteomics in cancer
faculty photo Kayvan Keshari, PhDNIH Pathway to Independence Awardee Sloan Kettering Bioactive Small Molecules: Chemical probe development, Macromolecular Structure and Function: Enzymology, NMR spectroscopy, Chemical Cell Biology: Cellular imaging, Metabolomics Cancer Cancer metabolism and metabolic imaging
faculty_photo_klinge_sebastian Sebastian Klinge, PhDNIH Director’s New Innovator Rockefeller Macromolecular Structure and Function: Enzymology, X-ray crystallography Structural aspects of eukaryotic ribosome assembly
faculty photo Joshua Levitz, PhD Weill Cornell Bioactive Small Molecules: Rational drug design, Chemical probe development,Macromolecular Structure and Function: Single molecule methods, Chemical Cell Biology: Cellular imaging, Biotechnology: Protein engineering Neuroscience Neurotransmitter receptor molecular biophysics and neurophysiology
faculty photo Yueming Li, PhD Sloan Kettering Bioactive Small Molecules: High-throughput screening assays, Chemical probe development, Macromolecular Structure and Function: Enzymology, Mass spectrometry, Chemical Cell Biology: Chemical genetics, Cellular imaging, Proteomics, Activity-based protein profiling Cancer, Neuroscience Biology of transmembrane proteases
faculty photo Christopher Lima, PhDHHMI Investigator
NIGMS MIRA Awardee
Sloan Kettering Macromolecular Structure and Function: Enzymology, X-ray crystallography Structural basis of protein sumoylation and RNA stability
faculty photo Shixin Liu, PhD Rockefeller Macromolecular Structure and Function: Enzymology, Single molecule methods, Chemical Cell Biology: Cellular imaging, Biotechnology: Nanotechnology Cancer, Microbiology, Virology Dynamic interplay of gene expression machineries
faculty photo Stephen Long, PhD Sloan Kettering Macromolecular Structure and Function: Enzymology, X-ray crystallography Cancer, Immunology, Neuroscience Structure and function of ion channels and membrane-embedded enzymes
faculty photo Minkui Luo, PhDNIH Director’s New Innovator Sloan Kettering Bioactive Small Molecules: High-throughput screening assays, Chemical probe development, Macromolecular Structure and Function: Enzymology, Chemical Cell Biology: Chemical genetics, Proteomics, Activity-based protein profiling, Biotechnology: Protein engineering Cancer, Neuroscience Protein post-translational modification and inhibitor design
faculty photo Roderick MacKinnon, MD2003 Nobel Prize in Chemistry
HHMI Investigator
Member, National Academy of Science
Rockefeller Bioactive Small Molecules: Chemical probe development, Macromolecular Structure and Function: X-ray crystallography, NMR spectroscopy Neuroscience Structure and function of ion channels and associated regulatory proteins
faculty photo Luciano Marraffini, PhDNIH Director’s New Innovator
HHMI Faculty Scholar
Rockefeller Macromolecular Structure and Function, Biotechnology Microbiology Bacteriology; mechanisms that prevent horizontal gene transfer
faculty photo Frederick Maxfield, PhD Weill Cornell Bioactive Small Molecules: High-throughput screening assays, Chemical Cell Biology: Cellular imaging Cardiovascular, Neuroscience Biophysical chemistry of membrane traffic
faculty photo Anant Menon, PhD Weill Cornell Bioactive Small Molecules: Chemical probe development, Macromolecular Structure and Function: Enzymology, Chemical Cell Biology: Cellular imaging, Proteomics Cardiovascular Trafficking of membrane lipids; protein lipidation and glycosylation
faculty photo Dimitar Nikolov, PhD Sloan Kettering Macromolecular Structure and Function: Enzymology, X-ray crystallography Neuroscience Structural biology of signaling in the nervous system
faculty photo Crina Nimigean, PhD Weill Cornell Macromolecular Structure and Function: X-ray crystallography, NMR spectroscopy, Single molecule methods, Biotechnology: Protein engineering, Nanotechnology Ion channel structure and mechanism
faculty photo Gavril Pasternak, MD, PhD Sloan Kettering Bioactive Small Molecules: Total synthesis, Rational drug design, High-throughput screening assays, Chemical probe development, Macromolecular Structure and Function, Chemical Cell Biology: Proteomics, Biotechnology: Radiochemistry, Computational Chemistry: Docking Neuroscience Neuroscience; opioid receptors and pharmacology
faculty photo Dinshaw Patel, PhDProfessor Emeritus
Member, National Academy of Science
Sloan Kettering Macromolecular Structure and Function: Enzymology, X-ray crystallography, NMR spectroscopy Cancer, Microbiology Structural biology of nucleic acids and nucleic acid binding proteins
faculty photo Nikola Pavletich, PhDHHMI Investigator
Member, National Academy of Science
Member, National Academy of Medicine
Sloan Kettering Macromolecular Structure and Function: Enzymology, X-ray crystallography Cancer Structural biology of the cell cycle
faculty photo Alexandros Pertsinidis, PhDNIH Director’s New Innovator Sloan Kettering Macromolecular Structure and Function: Single molecule methods, Chemical Cell Biology: Cellular imaging, Biotechnology: Nanotechnology Single-molecule and single-cell studies of gene regulation
faculty photo Neal Rosen, MD, PhDNCI Outstanding Investigator Sloan Kettering Bioactive Small Molecules: Chemical probe development, Chemical Cell Biology: Chemical genetics Cancer Mechanism-based therapeutic strategies for cancer
faculty photo Vanessa Ruta, PhDNIH Director’s New Innovator Rockefeller Macromolecular Structure and Function: X-ray crystallography, Chemical Cell Biology: Cellular imaging Neuroscience Neurophysiology and behavior; innate and adaptive animal neural circuits
faculty photo Timothy Ryan, PhD Weill Cornell Bioactive Small Molecules: High-throughput screening assays, Chemical probe development, Macromolecular Structure and Function: Single molecule methods, Chemical Cell Biology: Cellular imaging, Biotechnology Neuroscience Physical chemistry of the synapse
faculty photo Thomas Sakmar, MD Rockefeller Bioactive Small Molecules: Rational drug design, Chemical probe development, Macromolecular Structure and Function: X-ray crystallography, Single molecule methods, Chemical Cell Biology: Cellular imaging, Proteomics, Biotechnology: Protein engineering, Nanotechnology, Computational Chemistry: Protein modeling Diabetes, Neuroscience, Virology Molecular mechanisms of transmembrane signaling
faculty photo Anthony Sauve, PhD Weill Cornell Bioactive Small Molecules: Chemical methodology, Rational drug design, Chemical probe development, Macromolecular Structure and Function: Enzymology, Chemical Cell Biology: Chemical genetics Cancer Chemistry of ADP-ribosyltransferases and NAD
faculty photo David Scheinberg, MD, PhD Sloan Kettering Biotechnology: Protein engineering, Nanotechnology, Radiochemistry Cancer, Immunology Molecular pharmacology & chemistry; targeted immunotherapies
faculty photo Stewart Shuman, MD, PhD Sloan Kettering Bioactive Small Molecules: High-throughput screening assays, Macromolecular Structure and Function: Enzymology, X-ray crystallography Microbiology Nucleic acid metabolism
faculty photo Derek Tan, PhD Sloan Kettering Bioactive Small Molecules: Chemical methodology, Total synthesis, Rational drug design, Diversity-oriented synthesis, High-throughput screening assays, Chemical probe development, Computational Chemistry: Cheminformatics Cancer, Microbiology Diversity-oriented synthesis and rational drug design
faculty photo Pengbo Zhou, PhD Weill Cornell Bioactive Small Molecules: High-throughput screening assays, Chemical probe development, Rational drug design, Macromolecular Structure and Function: Enzymology, Mass spectrometry, Chemical Cell Biology: Chemical genetics, Proteomics, Biotechnology: Protein engineering Cancer, Neuroscience Physiological and pathological roles of ubiquitin-dependent protein destruction