PhD, 1975, Cornell University
BS, 1971, West Virginia Wesleyan College
2013 Breakthrough Prize in Life Sciences
Member, National Academy of Science
The Cantley lab utilizes genetically engineered mouse models and human cancer cell lines to understand the biochemical pathways by which oncogenes such as EGFR, PI3K, RAS and others mediate changes in cell metabolism, cell growth and cell transformation. A variety of approaches are being used to characterize these pathways, including inducible shRNA, mass spec proteomics and RNASeq. In addition, we are utilizing mass spec metabolomics to monitor the effect of inhibitors of these oncoproteins on the flux of metabolites in cancer cell lines and in tumors. These studies are revealing metabolic enzymes that could be targeted for treating cancers.