Weill Cornell Medical College The Rockefeller University Memorial Sloan-Kettering Cancer Center

Apply Online Application Due: December 1, 2013

TPCB Faculty

Anthony Sauve, PhD

Weill Cornell Medical College

Education

PhD, 1997, Princeton University

BA, 1986, University of California, Berkeley

Research Topics

  • Bioactive Small Molecules
    • Chemical methodology
    • Rational drug design
    • Chemical probe development
  • Macromolecular Structure and Function
    • Enzymology
    • Chemical Cell Biology
    • Chemical genetics

Therapeutic Areas

  • Cancer

photoADP-ribosyl-transferases participate in signaling pathways in bacteria, yeast, plants and humans and use NAD as a non-redox electrophile to accomplish post-translational modification of proteins or second messenger formation. Work in the Sauve lab explores 1. the biochemical principles of NAD activation, biochemical reaction mechanisms, and the regulation of enzyme activity, 2. the design and synthesis of small molecules that can either activate or inhibit these enzymes and the development of small molecule tools for the study of these enzymes in vivo.

Read more about Prof. Sauve’s research on the Weill Cornell website

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