MD, 1984, University of Tubingen
PhD, 1985, University of Tubingen
The second messenger molecule cAMP, which modulates cell growth and differentiation in organisms from bacteria to higher eukaryotes, is produced by adenylyl cyclases. Mammals possess two distinct classes of adenylyl cyclase, the hormone-responsive, transmembrane adenylyl cyclases (tmAC) and the bicarbonate-regulated Soluble Adenylyl Cyclase (sAC). sAC, which the Buck lab purified and cloned in collaboration with Dr. Lonny Levin’s lab, and tmACs define distinct cAMP signaling pathways within eukaryotic cells.