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TPCB Faculty

Jochen Buck, MD, PhD

Weill Cornell Medical College

Education

MD, 1984, University of Tubingen

PhD, 1985, University of Tubingen

Research Topics

  • Bioactive Small Molecules
    • Rational drug design
    • High-throughput screening assays
  • Macromolecular Structure and Function
    • Enzymology
  • Chemical Cell Biology
    • Proteomics
    • Metabolomics

Therapeutic Areas

  • Cancer
  • Cardiovascular
  • Diabetes
  • Microbiology

photoThe second messenger molecule cAMP, which modulates cell growth and differentiation in organisms from bacteria to higher eukaryotes, is produced by adenylyl cyclases. Mammals possess two distinct classes of adenylyl cyclase, the hormone-responsive, transmembrane adenylyl cyclases (tmAC) and the bicarbonate-regulated Soluble Adenylyl Cyclase (sAC). sAC, which the Buck lab purified and cloned in collaboration with Dr. Lonny Levin’s lab, and tmACs define distinct cAMP signaling pathways within eukaryotic cells.

Read more about Prof. Buck’s research on the Weill Cornell website

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