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TPCB is a leading PhD graduate program in chemical biology, offered jointly by three premier institutions in New York City. We provide an unparalleled combination of world-class faculty, state-of-the-art facilities, and collaborative research opportunities to the next generation of scientific leaders working at the interface of chemistry, biology, and medicine.
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All research labs at MSK, Rockefeller, and Weill Cornell are currently closed due to the COVID-19 pandemic. During this time, TPCB students are actively continuing their studies remotely, and are participating in enhanced online academic and social programming to keep our community intellectually engaged and socially connected. Our best wishes to all!
TPCB congratulates Rachel Leicher on receiving a Student Research Award and Travel Award from The Biophysical Society at their annual meeting in February. Rachel’s work with Prof. Shixin Liu at Rockefeller focuses on single-molecule studies of the role of the histone methyltransferase complex PRC2 in chromatin regulation. [more]
TPCB alumna Dr. Vidhya Rangaraju has launched her independent research program at the prestigious Max Planck Florida Institute for Neuroscience. Her lab aims to investigate how neurons manage mitochondrial energy use and supply. Vidhya completed her PhD training with TPCB faculty member Prof. Timothy Ryan. [more]
TPCB faculty member Prof. C. David Allis at Rockefeller has been elected to the National Academy of Medicine. Election to the Academy is one of the highest honors in science, and recognizes his pioneering work in epigenetics, discovering that covalent modifications of histone proteins regulate gene expression. [more]
TPCB congratulates our faculty on securing major NIH grants to support for innovative research in their labs. Prof. Brian Chait received an NIH Director’s Transformative Research Award, Prof. Samie Jaffrey received a NINDS Research Program Award, and Prof. Simon Scheuring received an NIH Director’s Pioneer Award. [more]
TPCB faculty member Prof. Vanessa Ruta has been named a 2019 MacArthur Fellow. Colloquially known as the “genius grant”, this award provides unrestricted support to individuals working across a wide range of disciplines in arts and sciences. Her research focuses on understanding how the brain responds to small-molecule odors. [more]
TPCB presented the 15th Annual Tri-Institutional Chemical Biology Symposium on September 4, 2019, featuring keynote talks by Profs. Benjamin Cravatt, Craig Crews, Vanessa Ruta, Cynthia Wolberger, and TPCB student talks by Darren Johnson, Lin Mei, and Linamarie Miller. Over 50 students and postdocs presented posters. [more]
TPCB congratulates Tandrila Das on her receipt of the Student Talk Award at the 2019 FASEB Science Research Conference on Protein Lipidation! Tandrila presented her work with Prof. Howard Hang at Rockefeller, studying the role of protein–lipid interactions in regulating the antiviral activity of a protein called IFITM3. [more]
TPCB student Fangyu Liu and colleagues in the lab of Prof. Jue Chen at Rockefeller have determined the structures of two drugs that potentiate the function of the CFTR ion channel, which is mutated in cystic fibrosis. The work paves the way for efforts in rational drug design and was published in the journal Science. [more]
The 2019 TPCB Student Career Development Retreat was held on August 7–8 at the Crystal Springs Resort. The event featured student research presentations, career development workshops, and a variety of social activities. The retreat was organized by TPCB students Adi Berman and Elizabeth Orth. [more]
The Tri-I Chemical Biology Summer Program (ChBSP) celebrated its second successful year, with six outstanding undergraduates spending the summer working on chemical biology projects in TPCB labs. The students presented their work at the Summer Undergraduate Poster Session at MSK on August 8. [more]
TPCB congratulates our 2019 graduates, Dr. Shi Chen (Luo Lab), Dr. Zhen Chen (Kapoor Lab), Dr. Alejandro Dottore (Kapoor Lab), Dr. Zachary Hann (Lima Lab), and Dr. Michaelyn Lux (Tan Lab). Our newest alumni carried out forefront research in chemical biology, studying protein structure and dynamics, and chemical probe synthesis. [more]
In a new eLife paper, a collaborative team lead by TPCB students Shi Chen and Rafal Wiewiora has used a combination of small-molecule inhibitors, biochemical assays, X-ray crystal structures, and massively parallel molecular dynamics simulations to understand the conformational landscape of the protein methyltransferase SETD8. [more]
TPCB partnered once again with the New York Academy of Sciences to present the annual NYAS Chemical Biology Symposium on May 22, 2019. The event featured keynote lectures by Dr. Emma Parmee (Merck), Prof. David Spiegel (Yale), and presentations from TPCB labs, including a short talk by TPCB student Ashley Chui. [more]
TPCB congratulates faculty members Prof. Yael David and Prof. Alex Kentsis on receiving the Pershing Square Sohn Prize. In addition, Prof. Vanessa Ruta, Prof. Tarun Kapoor, Prof. Stephen Long, and Prof. Minkui Luo have received prestigious NIH R35 grants for outstanding investigators. [more]
TPCB students Ashley Chui, Sahana Rao, and Jacob Litke have been awarded the 2019 Julian R. Rachele Prize. The prize recognizes their recent publications and is the highest award given to students by the Weill Cornell Graduate School. The winners will present their work at WCGS Convocation on May 29, 2019. [more]
TPCB is pleased to announce that faculty members Prof. Jue Chen and Prof. Luciano Marraffini have been elected to the National Academy of Sciences. Academy membership is considered one of the highest honors in science and recognizes distinguished and continuing achievements in original research. [more]
Congratulations to current TPCB student Adi Berman and incoming TPCB student Kristen Vogt, who have been awarded National Science Foundation Graduate Research Fellowships to support their PhD thesis research! They join five other current TPCB students who have received this prestigious fellowship. [more]
TPCB student Jacob Litke and Prof. Samie Jaffrey have developed a new platform called “Tornado” for expression of circular RNA aptamers in live cells. The work was published recently in Nature Biotechnology and opens the door to myriad applications of RNA aptamers as live-cell biosensors and inhibitors of cellular pathways. [more]
In a new Science paper, TPCB students Ashley Chui and Sahana Rao have uncovered the mechanism by which anthrax activates the innate immune response. The work in the lab of Prof. Dan Bachovchin also sheds light on the distinct mechanisms by which anticancer drugs activate a similar programmed cell death response. [more]
TPCB student Rudolf Pisa and faculty member Prof. Tarun Kapoor have developed highly selective inhibitors of spastin to probe the roles of this protein in cell division and intracellular vesicle transport. The work was published in two papers in Nature Chemical Biology and Journal of the American Chemical Society. [more]
TPCB students Wola Osunsade, Nick Prescott, Jake Hebert, and Devin Ray and faculty member Prof. Yael David have developed a robust new method to prepare H1 linker histones enabling detailed studies of their biochemical functions. The work was published in a special issue of the journal Biochemistry. [more]
In a new Cell paper, TPCB student Zhen Chen and faculty members Prof. Tarun Kapoor and Prof. Thomas Walz reveal novel molecular insights into the function of the AAA protein Mdn1 in ribosome biogenesis. The work leverages cryo-EM and a small-molecule inhibitor to uncover profound conformational changes in this assembly protein. [more]
Alumni Profile: TPCB alumni Dr. Renato Bauer and Dr. Jacqueline Wurst discuss the flexibility of the graduate program, the unique opportunities in the Tri-Institutional research environment, and how their training in chemistry prepared them for their current careers in the pharmaceutical industry at Eli Lilly. [more]
Student Profile: TPCB student Chaya Stern describes her non-traditional path to graduate school, where she is now working in Prof. John Chodera’s computational chemistry lab at Sloan Kettering as an NSF Graduate Research Fellow. She also discusses the support she has received from TPCB as a parent. [more]
Alumni Profile: TPCB alumna Prof. Niroshika Keppetipola discusses her training experience with mentor Prof. Stewart Shuman and how it prepared her for an independent academic career. Now a faculty member at Cal State Fullerton, her lab studies post-translational regulation of RNA binding proteins in alternative splicing. [more]
Faculty Profile: TPCB faculty member Prof. Yael David is a new faculty member at Sloan Kettering. She describe her lab’s approach using protein engineering to study epigenetic regulation and its correlation with disease states. She also discusses her approach to mentoring and her experiences as a woman in science. [more]
Alumni Profile: TPCB alumna Dr. Amy Grunbeck Perea developed photoactivatable probes to study G protein-coupled receptors with Prof. Tom Sakmar. After graduating with 9 papers on her CV, she did a postdoc fellowship at Genzyme, then joined Abcam, a biotech company in Cambridge, developing new tools for protein analysis. [more]
Faculty Profile: TPCB faculty member Prof. Jue Chen is an HHMI Investigator who studies the structure and function of molecular pumps called ABC transporters that are involved in many important biological processes. She discusses the recent cryo-EM ‘resolution revolution’ and her personalized approach to mentoring her students. [more]