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TPCB is a leading PhD graduate program in chemical biology, offered jointly by three premier institutions in New York City. We provide an unparalleled combination of world-class faculty, state-of-the-art facilities, and collaborative research opportunities to the next generation of scientific leaders working at the interface of chemistry, biology, and medicine.
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In a new paper eLife, a collaborative team led by TPCB student Lin Mei and Prof. Gregory Alushin at Rockefeller have uncovered fundamental new insights into the molecular mechanism by which cells detect mechanical signals from their environment, in which tension on the cytoskeletal protein actin leads to stronger binding of α-catenin. [more]
TPCB is now accepting applications for admission to the entering class of 2021! Please note that the deadline for receipt of all application materials, including letters of recommendation, is December 1, 2020. Selected students will be invited to attend our Open House event on January 18–20, 2021. [Start your application today!]
Our Diversity is Our Strength. TPCB has a long-standing commitment to promoting diversity and inclusion at all levels in science. Our outstanding students come from many different backgrounds and the program has zero tolerance for racism or discrimination in any form. We have taken numerous recent efforts to promote these principles. [more].
TPCB presented the 16th Annual Tri-Institutional Chemical Biology Symposium on September 1, 2020. The event was held online for the first time and expanded to over 350 registrants from around the world. The day featured faculty keynote lectures, student seminars, and over 50 poster presentations, representing the breadth of the field. [more]
TPCB welcomed its incoming class this summer! While their arrival in NYC was delayed due to the pandemic, they got a head start on their academic studies through a special curriculum including seminars, research ethics, and orientation and social events. The students arrived on campus in August to start their lab rotations. [more]
TPCB is excited to welcome three new faculty to the program! Prof. Heeseon An at and Prof. Viviana Risca and Prof. Ekaterina Vinogradova at Rockefeller bring exciting new research opportunities in using chemical tools to study cellular quality control, chromatin architecture, and immune cell function. [more]
The Tri-I Chemical Biology Summer Program (ChBSP) hosted five outstanding undergraduates this summer in TPCB labs. While the internships were remote this year due to the COVID-19 pandemic, the students participated in a wide range of training activities and presented their work at a virtual poster session on July 31. [more]
With labs closed in mid-March due to the COVID-19 pandemic, TPCB students remained intellectually engaged and socially connected through a variety of online scientific and social activities. TPCB also worked to promote mental health awareness during the pause, and the resilience and commitment of our students was on full display. [more]
Congratulations to TPCB student Sahana Rao, who has received a Kravis Women in Science Endeavor Graduate Fellowship, Prof. Daniel Heller, who was honored with the Weill Cornell Outstanding Teaching and Mentoring Award, and Prof. Alex Kentsis, who was recognized with the MSK Boyer Award for Clinical Research! [more]
TPCB partnered with the New York Academy of Sciences to present the annual NYAS Chemical Biology Symposium on May 21, 2020. The event featured keynote lectures by Prof. Anna Marie Pyle (Yale), Dr. Elaine Pinheiro (Merck), and presentations from TPCB labs, including short talks by Rachel Leicher and Adewola Osunsade. [more]
TPCB congratulates our 2020 graduates, Dr. Ashley Chui (Bachovchin Lab), Dr. Alexis Jaramillo Cartagena (Darst Lab), Dr. Darren Johnson (Bachovchin Lab), Dr. Jacob Litke (Jaffrey Lab), Dr. Rudolf Pisa (Kapoor Lab), Dr. Cristina Santarossa (Kapoor Lab), and Dr. Chaya Stern (Chodera Lab). All will be continuing their careers in science. [more]
TPCB is pleased to partner with the New York Academy of Sciences to present the annual NYAS Chemical Biology Symposium on May 21, 2020. This online event will feature keynote lectures by Prof. Anna Marie Pyle (Yale) and Dr. Eliane Pinheiro (Merck) as well as talks and posters by students from NYC-area labs. [Register here]
TPCB congratulates faculty member Prof. Christopher Lima at MSK on his election to the National Academy of Sciences. Academy membership is considered one of the highest honors in science and recognizes Prof. Lima’s distinguished achievements in studying the structural biology and biochemistry of ubiquitin conjugation and the RNA exosome. [more]
Congratulations to our students and alumni on their recent accolades! Ashley Chui was featured in the MSK Women in Science series for her work with Prof. Dan Bachovchin. Dr. Sydney Lu has been awarded a fellowship by the Parker Institute. Dr. Yuan Shi has been highlighted for his work in drug discovery at Eli Lilly. [more]
TPCB congratulates Rachel Leicher on receiving a Student Research Award and Travel Award from The Biophysical Society at their annual meeting in February. Rachel’s work with Prof. Shixin Liu at Rockefeller focuses on single-molecule studies of the role of the histone methyltransferase complex PRC2 in chromatin regulation. [more]
TPCB alumna Dr. Vidhya Rangaraju has launched her independent research program at the prestigious Max Planck Florida Institute for Neuroscience. Her lab aims to investigate how neurons manage mitochondrial energy use and supply. Vidhya completed her PhD training with TPCB faculty member Prof. Timothy Ryan. [more]
TPCB faculty member Prof. C. David Allis at Rockefeller has been elected to the National Academy of Medicine. Election to the Academy is one of the highest honors in science, and recognizes his pioneering work in epigenetics, discovering that covalent modifications of histone proteins regulate gene expression. [more]
TPCB faculty member Prof. Vanessa Ruta has been named a 2019 MacArthur Fellow. Colloquially known as the “genius grant”, this award provides unrestricted support to individuals working across a wide range of disciplines in arts and sciences. Her research focuses on understanding how the brain responds to small-molecule odors. [more]
TPCB presented the 15th Annual Tri-Institutional Chemical Biology Symposium on September 4, 2019, featuring keynote talks by Profs. Benjamin Cravatt, Craig Crews, Vanessa Ruta, Cynthia Wolberger, and TPCB student talks by Darren Johnson, Lin Mei, and Linamarie Miller. Over 50 students and postdocs presented posters. [more]
TPCB congratulates Tandrila Das on her receipt of the Student Talk Award at the 2019 FASEB Science Research Conference on Protein Lipidation! Tandrila presented her work with Prof. Howard Hang at Rockefeller, studying the role of protein–lipid interactions in regulating the antiviral activity of a protein called IFITM3. [more]
TPCB student Fangyu Liu and colleagues in the lab of Prof. Jue Chen at Rockefeller have determined the structures of two drugs that potentiate the function of the CFTR ion channel, which is mutated in cystic fibrosis. The work paves the way for efforts in rational drug design and was published in the journal Science. [more]
The 2019 TPCB Student Career Development Retreat was held on August 7–8 at the Crystal Springs Resort. The event featured student research presentations, career development workshops, and a variety of social activities. The retreat was organized by TPCB students Adi Berman and Elizabeth Orth. [more]
TPCB congratulates our 2019 graduates, Dr. Shi Chen (Luo Lab), Dr. Zhen Chen (Kapoor Lab), Dr. Alejandro Dottore (Kapoor Lab), Dr. Zachary Hann (Lima Lab), and Dr. Michaelyn Lux (Tan Lab). Our newest alumni carried out forefront research in chemical biology, studying protein structure and dynamics, and chemical probe synthesis. [more]
In a new eLife paper, a collaborative team lead by TPCB students Shi Chen and Rafal Wiewiora has used a combination of small-molecule inhibitors, biochemical assays, X-ray crystal structures, and massively parallel molecular dynamics simulations to understand the conformational landscape of the protein methyltransferase SETD8. [more]
Alumni Profile: TPCB alumni Dr. Renato Bauer and Dr. Jacqueline Wurst discuss the flexibility of the graduate program, the unique opportunities in the Tri-Institutional research environment, and how their training in chemistry prepared them for their current careers in the pharmaceutical industry at Eli Lilly. [more]
Student Profile: TPCB student Chaya Stern describes her non-traditional path to graduate school, where she is now working in Prof. John Chodera’s computational chemistry lab at Sloan Kettering as an NSF Graduate Research Fellow. She also discusses the support she has received from TPCB as a parent. [more]
Alumni Profile: TPCB alumna Prof. Niroshika Keppetipola discusses her training experience with mentor Prof. Stewart Shuman and how it prepared her for an independent academic career. Now a faculty member at Cal State Fullerton, her lab studies post-translational regulation of RNA binding proteins in alternative splicing. [more]
Faculty Profile: TPCB faculty member Prof. Yael David is a new faculty member at Sloan Kettering. She describe her lab’s approach using protein engineering to study epigenetic regulation and its correlation with disease states. She also discusses her approach to mentoring and her experiences as a woman in science. [more]
Alumni Profile: TPCB alumna Dr. Amy Grunbeck Perea developed photoactivatable probes to study G protein-coupled receptors with Prof. Tom Sakmar. After graduating with 9 papers on her CV, she did a postdoc fellowship at Genzyme, then joined Abcam, a biotech company in Cambridge, developing new tools for protein analysis. [more]
Faculty Profile: TPCB faculty member Prof. Jue Chen is an HHMI Investigator who studies the structure and function of molecular pumps called ABC transporters that are involved in many important biological processes. She discusses the recent cryo-EM ‘resolution revolution’ and her personalized approach to mentoring her students. [more]