PhD, 2012, University of California, Berkeley
BS, 2004, Stanford University
The Risca Lab studies how the three-dimensional architecture of the genome reflects and regulates DNA-based processes. We are particularly interested in mechanisms of transcriptional repression and regulation of access to DNA in differentiation and senescence. Our analytical approaches include sequencing-based epigenomic assays, in vitro reconstitution, microscopy, and coarse-grained modeling of chromatin fibers using Monte Carlo simulations. We are developing novel methods for probing chromatin structure in minimally perturbed cells using ionizing radiation and hydroxyl radical generating chemical probes.