PhD, 1992, University of California, Berkeley
MS, 1984, Chinese Academy of Sciences
BS, 1982, Shanxi Agriculture University
The main interest of the Li lab is to study regulated intramembrane proteolysis (RIP) and signal transduction. RIP has emerged as a novel-signaling paradigm in the new millennium. Intramembrane cleavage proteases not only serve as highly effective post-translational regulators of protein function but also represent a unique class of enzymes that catalyze substrate hydrolysis within transmembrane domains. Two intramembrane proteases — gamma-secretase and Rhomboid-mediated intramembrane serine protease are under investigation in our lab, utilizing the powerful tools of molecular biology, protein chemistry, chemistry, and proteomics.