Organic Chemistry in TPCB
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Organic Synthesis Plays a Central Role in TPCB Research
Synthetic organic chemistry enables the construction of biologically active molecules and provides powerful tools for chemical biology research. Organic synthesis plays a central role in TPCB research and our students have access to comprehensive resources and facilities to support these efforts across all three institutions.
Three complete laboratory floors on our campuses are dedicated to organic synthesis and are fully-equipped with chemical fume hoods, chemistry benches, equipment rooms, and chemical storage rooms. Our state-of-the-art instrumentation, housed in our analytical chemistry core facilities and maintained by professional support staff, includes high-field NMR spectrometers (500 and 600 MHz, including four with cryoprobes), mass spectrometers (LC-MS, LC-TOF-MS, LC-MS/MS, GC-MS), spectrophotometers (FTIR, UV-Vis, CD, polarimetry), and analytical and preparative chromatography instruments (UPLC, HPLC, SFC, AutoPurification, CombiFlash) with various combinations of MS, PDA, and ELSD detectors.
Our research libraries provide online access to all major chemistry journals through institutional subscriptions. Our students have access to a full suite of major chemistry software packages, including SciFinder, Reaxys, Schrödinger Drug Discovery Suite, ChemDraw, PyMOL, MacSpartan, Pipeline Pilot, MestReNova, ACD/NMR Predictor, and Prism. The Tri-Institutional Therapeutics Discovery Institute (http://triitdi.org/) provides a unique and outstanding resource for students interested in translational research, collaborating with TPCB laboratories to support efforts in molecular modeling, virtual screening, high-throughput screening, medicinal chemistry, and preclinical pharmacology and toxicology.
Finally, TPCB students receive advanced training in organic chemistry through graduate level coursework offered at Rockefeller University, Weill Cornell Medicine, Columbia University, and the City University of New York.