Weill Cornell Medical College The Rockefeller University Memorial Sloan-Kettering Cancer Center

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Publications

Student publications at the forefront of chemical biology

TPCB students have an exceptional publication record, averaging over 5 papers per PhD graduate! This prolific group has published over 500 scientific papers since 2003, in high impact journals including Nature, Science, Cell, Journal of the American Chemical Society, ACS Chemical Biology, Biochemistry, Cell Chemical Biology, Nature Chemical Biology, and Proceedings of the National Academy of Sciences. Because of our highly interactive research environment, many of these papers involve multidisciplinary collaborations between TPCB laboratories as well as with other researchers on the Tri-Institutional campuses. In total, TPCB labs have published over 200 papers together!

Name Publications
Banerjee, Anoosha Small, G. I.; Fedorova, O.; Olinares, P. D. B.; Chandanani, J.; Banerjee, A.; Choi, Y. J.; Molina, H.; Chait, B. T.; Darst, S. A.; Campbell, E. A. Structural and functional insights into the enzymatic plasticity of the SARS-CoV-2 NiRAN domain. Mol. Cell 2023, 83, 3921-3930.e7. DOI: 10.1016/j.molcel.2023.10.001 PMID: 37890482
Grimes, S. L.; Choi, Y. J.; Banerjee, A.; Small, G.; Anderson-Daniels, J.; Gribble, J.; Pruijssers, A. J.; Agostini, M. L.; Abu-Shmais, A.; Lu, X.; Darst, S. A.; Campbell, E.; Denison, M. R. A mutation in the coronavirus nsp13-helicase impairs enzymatic activity and confers partial remdesivir resistance. mBio 2023, 14, e0106023. DOI: 10.1128/mbio.01060-23 PMID: 37338298
Banerjee, Sourabh Menon, I.; Huber, T.; Sanyal, S.; Banerjee, S.; Barré, P.; Canis, S.; Warren, J. D.; Hwa, J.; Sakmar, T. P.; Menon, A. K. Opsin is a phospholipid flippase. Curr. Biol. 2011, 21, 149–153. DOI: 10.1016/j.cub.2010.12.031 PMID: 21236677
Knepp, A. M.; Grunbeck, A.; Banerjee, S.; Sakmar, T. P.; Huber, T. Direct measurement of thermal stability of expressed CCR5 and stabilization by small molecule ligands. Biochemistry 2011, 50, 502–511. DOI: 10.1021/bi101059w PMID: 21155586
Zaitseva, E.; Saavedra, M.; Banerjee, S.; Sakmar, T. P.; Vogel, R. SEIRA spectroscopy on a membrane receptor monolayer using lipoprotein particles as carriers. Biophys. J. 2010, 99, 2327–2335. DOI: 10.1016/j.bpj.2010.06.054 PMID: 20923668
Banerjee, S.; Huber, T.; Sakmar, T. P. Rapid incorporation of functional rhodopsin into nanoscale apolipoprotein bound bilayer (NABB) particles. J. Mol. Biol. 2008, 377, 1067–1081. DOI: 10.1016/j.jmb.2008.01.066 PMID: 18313692
Baca, Christian Baca, C. F.; Yu, Y.; Rostøl, J. T.; Majumder, P.; Patel, D. J.; Marraffini, L. A. The CRISPR effector Cam1 mediates membrane depolarization for phage defence. Nature 2024, in press. DOI: 10.1038/s41586-023-06902-y PMID: 38200316
Banik, Jacob Charlop-Powers, Z.; Banik, J. J.; Owen, J. G.; Craig, J. W.; Brady, S. F. Selective enrichment of environmental DNA libraries for genes encoding nonribosomal peptides and polyketides by phosphopantetheine transferase-dependent complementation of siderophore biosynthesis. ACS Chem. Biol. 2013, 8, 138–143. DOI: 10.1021/cb3004918 PMID: 23072412
Bick, M. J.; Banik, J. J.; Darst, S. A.; Brady, S. F. The 2.7 Å resolution structure of the glycopeptide sulfotransferase Teg14. Acta Crystallogr. D Biol. Crystallogr. 2010, 66, 1278–1286. DOI: 10.1107/S0907444910036681 PMID: 21123867
Banik, J. J.; Craig, J. W.; Calle, P. Y.; Brady, S. F. Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products. J. Am. Chem. Soc. 2010, 132, 15661–15670. DOI: 10.1021/ja105825a PMID: 20945895
Banik, J. J.; Brady, S. F. Recent application of metagenomic approaches toward the discovery of antimicrobials and other bioactive small molecules. Curr. Opin. Microbiol. 2010, 13, 603–609. DOI: 10.1016/j.mib.2010.08.012 PMID: 20884282
Bick, M. J.; Banik, J. J.; Darst, S. A.; Brady, S. F. Crystal structures of the glycopeptide sulfotransferase Teg12 in a complex with the teicoplanin aglycone. Biochemistry 2010, 49, 4159–4168. DOI: 10.1021/bi100150v PMID: 20361791
Banik, J. J.; Brady, S. F. Cloning and characterization of new glycopeptide gene clusters found in an environmental DNA megalibrary. Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 17273–17277. DOI: 10.1073/pnas.0807564105 PMID: 18987322
Bauer, Renato Wenderski, T. A.; Stratton, C. F.; Bauer, R. A.; Kopp, F.; Tan, D. S. Principal component analysis as a tool for library design: a case study investigating natural products, brand-name drugs, natural product-like libraries, and drug-like libraries. Methods Mol. Biol. 2015, 1263, 225–242. DOI: 10.1007/978-1-4939-2269-7_18 PMID: 25618349
Bauer, R. A.; Wenderski, T. A.; Tan, D. S. Biomimetic diversity-oriented synthesis of benzannulated medium rings via ring expansion. Nat. Chem. Biol. 2012, 9, 21–29. DOI: 10.1038/nchembio.1130 PMID: 23160003
Moura-Letts, G.; DiBlasi, C. M.; Bauer, R. A.; Tan, D. S. Solid-phase synthesis and chemical space analysis of a 190-membered alkaloid/terpenoid-like library. Proc. Natl. Acad. Sci. U.S.A. 2011, 108, 6745–6750. DOI: 10.1073/pnas.1015268108 PMID: 21451137
Bauer, R. A.; DiBlasi, C. M.; Tan, D. S. The tert-butylsulfinamide lynchpin in transition-metal-mediated multiscaffold library synthesis. Org. Lett. 2010, 12, 2084–2087. DOI: 10.1021/ol100574y PMID: 20356070
Bauer, R. A.; Wurst, J. M.; Tan, D. S. Expanding the range of ‘druggable’ targets with natural product-based libraries: an academic perspective. Curr. Opin. Chem. Biol. 2010, 14, 308–314. DOI: 10.1016/j.cbpa.2010.02.001 PMID: 20202892
Berman, Adi Kelley, M. E.; Berman, A. Y.; Stirling, D. R.; Cimini, B. A.; Han, Y.; Singh, S.; Carpenter, A. E.; Kapoor, T. M.; Way, G. P. High-content microscopy reveals a morphological signature of bortezomib resistance. eLife 2023, 12, e91362. DOI: 10.7554/eLife.91362 PMID: 37753907
Berman, A. Y.; Wieczorek, M.; Aher, A.; Olinares, P. D. B.; Chait, B. T.; Kapoor, T. M. A nucleotide binding-independent role for γ-tubulin in microtubule capping and cell division. J. Cell. Biol. 2023, 222, e202204102. DOI: 10.1083/jcb.202204102 PMID: 36695784
Blum, Gil Chen, S.; Wiewiora, R. P.; Meng, F.; Babault, N.; Ma, A.; Yu, W.; Qian, K.; Hu, H.; Zou, H.; Wang, J.; Fan, S.; Blum, G.; Pittella-Silva, F.; Beauchamp, K. A.; Tempel, W.; Jiang, H.; Chen, K.; Skene, R. J.; Zheng, Y. G.; Brown, P. J.; Jin, J.; Luo, C.; Chodera, J. D.; Luo, M. The dynamic conformational landscape of the protein methyltransferase SETD8. eLife 2019, 8, e45403. DOI: 10.7554/eLife.45403 PMID: 31081496
Linscott, J. A.; Kapilashrami, K.; Wang, Z.; Senevirathne, C.; Bothwell, I. R.; Blum, G.; Luo, M. Kinetic isotope effects reveal early transition state of protein lysine methyltransferase SET8. Proc. Natl. Acad. Sci. U.S.A. 2016, 113, E8369-E8378. DOI: 10.1073/pnas.1609032114 PMID: 27940912
LaFave, L. M.; Béguelin, W.; Koche, R.; Teater, M.; Spitzer, B.; Chramiec, A.; Papalexi, E.; Keller, M. D.; Hricik, T.; Konstantinoff, K.; Micol, J. B.; Durham, B.; Knutson, S. K.; Campbell, J. E.; Blum, G.; Shi, X.; Doud, E. H.; Krivtsov, A. V.; Chung, Y. R.; Khodos, I.; de Stanchina, E.; Ouerfelli, O.; Adusumilli, P. S.; Thomas, P. M.; Kelleher, N. L.; Luo, M.; Keilhack, H.; Abdel-Wahab, O.; Melnick, A.; Armstrong, S. A.; Levine, R. L. Loss of BAP1 function leads to EZH2-dependent transformation. Nat. Med. 2015, 21, 1344–1349. DOI: 10.1038/nm.3947 PMID: 26437366
Blum, G.; Ibáñez, G.; Rao, X.; Shum, D.; Radu, C.; Djaballah, H.; Rice, J. C.; Luo, M. Small-molecule inhibitors of SETD8 with cellular activity. ACS Chem. Biol. 2014, 9, 2471–2478. DOI: 10.1021/cb500515r PMID: 25137013
Guo, H.; Wang, R.; Zheng, W.; Chen, Y.; Blum, G.; Deng, H.; Luo, M. Profiling substrates of protein arginine N-methyltransferase 3 with S-adenosyl-L-methionine analogues. ACS Chem. Biol. 2014, 9, 476–484. DOI: 10.1021/cb4008259 PMID: 24320160
Islam, K.; Chen, Y.; Wu, H.; Bothwell, I. R.; Blum, G. J.; Zeng, H.; Dong, A.; Zheng, W.; Min, J.; Deng, H.; Luo, M. Defining efficient enzyme-cofactor pairs for bioorthogonal profiling of protein methylation. Proc. Natl. Acad. Sci. U.S.A. 2013, 110, 16778–16783. DOI: 10.1073/pnas.1216365110 PMID: 24082136
Blum, G.; Bothwell, I. R.; Islam, K.; Luo, M. Profiling protein methylation with cofactor analog containing terminal alkyne functionality. Curr. Protoc. Chem. Biol. 2013, 5, 67–88. DOI: 10.1002/9780470559277.ch120241 PMID: 23788324
Blum, G.; Islam, K.; Luo, M. Bioorthogonal profiling of protein methylation (BPPM) using an azido analog of S-adenosyl-L-methionine. Curr. Protoc. Chem. Biol. 2013, 5, 45–66. DOI: 10.1002/9780470559277.ch120240 PMID: 23667794
Wang, R.; Islam, K.; Liu, Y.; Zheng, W.; Tang, H.; Lailler, N.; Blum, G.; Deng, H.; Luo, M. Profiling genome-wide chromatin methylation with engineered posttranslation apparatus within living cells. J. Am. Chem. Soc. 2013, 135, 1048–1056. DOI: 10.1021/ja309412s PMID: 23244065
Zheng, W.; Ibáñez, G.; Wu, H.; Blum, G.; Zeng, H.; Dong, A.; Li, F.; Hajian, T.; Allali-Hassani, A.; Amaya, M. F.; Siarheyeva, A.; Yu, W.; Brown, P. J.; Schapira, M.; Vedadi, M.; Min, J.; Luo, M. Sinefungin derivatives as inhibitors and structure probes of protein lysine methyltransferase SETD2. J. Am. Chem. Soc. 2012, 134, 18004–18014. DOI: 10.1021/ja307060p PMID: 23043551
Bothwell, I. R.; Islam, K.; Chen, Y.; Zheng, W.; Blum, G.; Deng, H.; Luo, M. Se-adenosyl-L-selenomethionine cofactor analogue as a reporter of protein methylation. J. Am. Chem. Soc. 2012, 134, 14905–14912. DOI: 10.1021/ja304782r PMID: 22917021
Ibanez, G.; Shum, D.; Blum, G.; Bhinder, B.; Radu, C.; Antczak, C.; Luo, M.; Djaballah, H. A high throughput scintillation proximity imaging assay for protein methyltransferases. Comb. Chem. High Throughput Screen. 2012, 15, 359–371. DOI: 10.2174/138620712800194468 PMID: 22256970
Wang, R.; Ibáñez, G.; Islam, K.; Zheng, W.; Blum, G.; Sengelaub, C.; Luo, M. Formulating a fluorogenic assay to evaluate S-adenosyl-L-methionine analogues as protein methyltransferase cofactors. Mol. Biosyst. 2011, 7, 2970–2981. DOI: 10.1039/c1mb05230f PMID: 21866297
Bose, Neelanjan Shinoda, K.; Choe, A.; Hirahara, K.; Kiuchi, M.; Kokubo, K.; Ichikawa, T.; Hoki, J. S.; Suzuki, A. S.; Bose, N.; Appleton, J. A.; Aroian, R. V.; Schroeder, F. C.; Sternberg, P. W.; Nakayama, T. Nematode ascarosides attenuate mammalian type 2 inflammatory responses. Proc Natl Acad Sci U S A 2022, 119, e2108686119. DOI: 10.1073/pnas.2108686119 PMID: 35210367
Falcke, J. M.; Bose, N.; Artyukhin, A. B.; Rödelsperger, C.; Markov, G. V.; Yim, J. J.; Grimm, D.; Claassen, M. H.; Panda, O.; Baccile, J. A.; Zhang, Y. K.; Le, H. H.; Jolic, D.; Schroeder, F. C.; Sommer, R. J. Linking genomic and metabolomic natural variation uncovers nematode pheromone biosynthesis. Cell Chem. Biol. 2018, 25, 787–796. DOI: 10.1016/j.chembiol.2018.04.004 PMID: 29779955
Liu, Z.; Kariya, M. J.; Chute, C. D.; Pribadi, A. K.; Leinwand, S. G.; Tong, A.; Curran, K. P.; Bose, N.; Schroeder, F. C.; Srinivasan, J.; Chalasani, S. H. Predator-secreted sulfolipids induce defensive responses in C. elegans. Nat. Commun. 2018, 9, 1128. DOI: 10.1038/s41467-018-03333-6 PMID: 29555902
Narayan, A.; Venkatachalam, V.; Durak, O.; Reilly, D. K.; Bose, N.; Schroeder, F. C.; Samuel, A. D.; Srinivasan, J.; Sternberg, P. W. Contrasting responses within a single neuron class enable sex-specific attraction in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U.S.A. 2016, 113, E1392–E1401. DOI: 10.1073/pnas.1600786113 PMID: 26903633
Chaudhuri, J.; Bose, N.; Tandonnet, S.; Adams, S.; Zuco, G.; Kache, V.; Parihar, M.; von Reuss, S. H.; Schroeder, F. C.; Pires-daSilva, A. Mating dynamics in a nematode with three sexes and its evolutionary implications. Sci. Rep. 2015, 5, 17676. DOI: 10.1038/srep17676 PMID: 26631423
Yim, J. J.; Bose, N.; Meyer, J. M.; Sommer, R. J.; Schroeder, F. C. Nematode signaling molecules derived from multimodular assembly of primary metabolic building blocks. Org. Lett. 2015, 17, 1648–1651. DOI: 10.1021/acs.orglett.5b00329 PMID: 25782998
Zugasti, O.; Bose, N.; Squiban, B.; Belougne, J.; Kurz, C. L.; Schroeder, F. C.; Pujol, N.; Ewbank, J. J. Activation of a G protein-coupled receptor by its endogenous ligand triggers the innate immune response of Caenorhabditis elegans. Nat. Immunol. 2014, 15, 833–838. DOI: 10.1038/ni.2957 PMID: 25086774
Bose, N.; Meyer, J. M.; Yim, J. J.; Mayer, M. G.; Markov, G. V.; Ogawa, A.; Schroeder, F. C.; Sommer, R. J. Natural variation in dauer pheromone production and sensing supports intraspecific competition in nematodes. Curr. Biol. 2014, 24, 1536–1541. DOI: 10.1016/j.cub.2014.05.045 PMID: 24980503
Mahanti, P.; Bose, N.; Bethke, A.; Judkins, J. C.; Wollam, J.; Dumas, K. J.; Zimmerman, A. M.; Campbell, S. L.; Hu, P. J.; Antebi, A.; Schroeder, F. C. Comparative metabolomics reveals endogenous ligands of DAF-12, a nuclear hormone receptor, regulating C. elegans development and lifespan. Cell Metab. 2014, 19, 73–83. DOI: 10.1016/j.cmet.2013.11.024 PMID: 24411940
Artyukhin, A. B.; Yim, J. J.; Srinivasan, J.; Izrayelit, Y.; Bose, N.; von Reuss, S. H.; Jo, Y.; Jordan, J. M.; Baugh, L. R.; Cheong, M.; Sternberg, P. W.; Avery, L.; Schroeder, F. C. Succinylated octopamine ascarosides and a new pathway of biogenic amine metabolism in Caenorhabditis elegans. J. Biol. Chem. 2013, 288, 18778–18783. DOI: 10.1074/jbc.C113.477000 PMID: 23689506
Izrayelit, Y.; Robinette, S. L.; Bose, N.; von Reuss, S. H.; Schroeder, F. C. 2D NMR-based metabolomics uncovers interactions between conserved biochemical pathways in the model organism Caenorhabditis elegans. ACS Chem. Biol. 2013, 8, 314–319. DOI: 10.1021/cb3004644 PMID: 23163760
Bose, N.; Ogawa, A.; von Reuss, S. H.; Yim, J. J.; Ragsdale, E. J.; Sommer, R. J.; Schroeder, F. C. Complex small-molecule architectures regulate phenotypic plasticity in a nematode. Angew. Chem. Int. Ed. Engl. 2012, 51, 12438–12443. DOI: 10.1002/anie.201206797 PMID: 23161728
Srinivasan, J.; von Reuss, S. H.; Bose, N.; Zaslaver, A.; Mahanti, P.; Ho, M. C.; O’Doherty, O. G.; Edison, A. S.; Sternberg, P. W.; Schroeder, F. C. A modular library of small molecule signals regulates social behaviors in Caenorhabditis elegans. PLoS Biol. 2012, 10, e1001237. DOI: 10.1371/journal.pbio.1001237 PMID: 22253572
von Reuss, S. H.; Bose, N.; Srinivasan, J.; Yim, J. J.; Judkins, J. C.; Sternberg, P. W.; Schroeder, F. C. Comparative metabolomics reveals biogenesis of ascarosides, a modular library of small-molecule signals in C. elegans. J. Am. Chem. Soc. 2012, 134, 1817–1824. DOI: 10.1021/ja210202y PMID: 22239548
Bothwell, Ian Shu, X.; Dai, Q.; Wu, T.; Bothwell, I. R.; Yue, Y.; Zhang, Z.; Cao, J.; Fei, Q.; Luo, M.; He, C.; Liu, J. N6-Allyladenosine: A new small molecule for RNA labeling identified by mutation assay. J. Am. Chem. Soc. 2017, 139, 17213–17216. DOI: 10.1021/jacs.7b06837 PMID: 29116772
Linscott, J. A.; Kapilashrami, K.; Wang, Z.; Senevirathne, C.; Bothwell, I. R.; Blum, G.; Luo, M. Kinetic isotope effects reveal early transition state of protein lysine methyltransferase SET8. Proc. Natl. Acad. Sci. U.S.A. 2016, 113, E8369-E8378. DOI: 10.1073/pnas.1609032114 PMID: 27940912
Bothwell, I. R.; Luo, M. Large-scale, protection-free synthesis of Se-adenosyl-L-selenomethionine analogues and their application as cofactor surrogates of methyltransferases. Org. Lett. 2014, 16, 3056–3059. DOI: 10.1021/ol501169y PMID: 24852128
Islam, K.; Chen, Y.; Wu, H.; Bothwell, I. R.; Blum, G. J.; Zeng, H.; Dong, A.; Zheng, W.; Min, J.; Deng, H.; Luo, M. Defining efficient enzyme-cofactor pairs for bioorthogonal profiling of protein methylation. Proc. Natl. Acad. Sci. U.S.A. 2013, 110, 16778–16783. DOI: 10.1073/pnas.1216365110 PMID: 24082136
Winter, J. M.; Chiou, G.; Bothwell, I. R.; Xu, W.; Garg, N. K.; Luo, M.; Tang, Y. Expanding the structural diversity of polyketides by exploring the cofactor tolerance of an inline methyltransferase domain. Org. Lett. 2013, 15, 3774–3777. DOI: 10.1021/ol401723h PMID: 23837609
Blum, G.; Bothwell, I. R.; Islam, K.; Luo, M. Profiling protein methylation with cofactor analog containing terminal alkyne functionality. Curr. Protoc. Chem. Biol. 2013, 5, 67–88. DOI: 10.1002/9780470559277.ch120241 PMID: 23788324
Bothwell, I. R.; Islam, K.; Chen, Y.; Zheng, W.; Blum, G.; Deng, H.; Luo, M. Se-adenosyl-L-selenomethionine cofactor analogue as a reporter of protein methylation. J. Am. Chem. Soc. 2012, 134, 14905–14912. DOI: 10.1021/ja304782r PMID: 22917021
Islam, K.; Bothwell, I.; Chen, Y.; Sengelaub, C.; Wang, R.; Deng, H.; Luo, M. Bioorthogonal profiling of protein methylation using azido derivative of S-adenosyl-L-methionine. J. Am. Chem. Soc. 2012, 134, 5909–5915. DOI: 10.1021/ja2118333 PMID: 22404544
Burnside, Chloe Harper, N. J.†; Burnside, C.†; Klinge, S. Principles of mitoribosomal small subunit assembly in eukaryotes. Nature 2023, 614, 175–181. DOI: 10.1038/s41586-022-05621-0 PMID: 36482135
Cahir, Clare Yang, L.; Han, Y.; Zhou, T.; Lacko, L. A.; Saeed, M.; Tan, C.; Danziger, R.; Zhu, J.; Zhao, Z.; Cahir, C.; Giana, A. M.; Li, Y.; Dong, X.; Moroziewicz, D.; NYSCF Global Stem Cell Array® Team; Paull, D.; Chen, Z.; Zhong, A.; Noggle, S. A.; Rice, C. M.; Qi, Q.; Evans, T.; Chen, S. Isogenic human trophectoderm cells demonstrate the role of NDUFA4 and associated variants in ZIKV infection. iScience 2023, 26, 107001. DOI: 10.1016/j.isci.2023.107001 PMID: 37534130
Han, Y.; Tan, L.; Zhou, T.; Yang, L.; Carrau, L.; Lacko, L. A.; Saeed, M.; Jiajun, Z.; Zhao, Z.; Nilsson-Payant, B. E.; Tenorio Lira Neto, F.; Cahir, C.; Giana, A. M.; Chai, J. C.; Li, Y.; Dong, X.; Moroziewicz, D.; NYSCF Global Stem Cell Array Team; Paull, D; Zhang, T.; Koo, S.; Tan, C.; Danziger, R.; Ba, Q.; Feng, L; Chen, Z.; Zhong, A.; Wise, G. J.; Xiang, J. Z.; Wang, H.; Schwartz, R. E.; tenOever, B. R.; Noggle, S. A.; Rice, C. M.; Qi, Q.; Evans, T.; Chen, S. A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants. Cell Stem Cell 2022, 29, 1475-1490. DOI: 10.1016/j.stem.2022.09.008 PMID: 36206731
Carl, Ayala Reynolds, M. J.; Hachicho, C.; Carl, A. G.; Gong, R.; Alushin, G. M. Bending forces and nucleotide state jointly regulate F-actin structure. Nature 2022, 611, 380–386. DOI: 10.1038/s41586-022-05366-w PMID: 36289330
Uson, M. L.; Carl, A.; Goldgur, Y.; Shuman, S. Crystal structure and mutational analysis of Mycobacterium smegmatis FenA highlight active site amino acids and three metal ions essential for flap endonuclease and 5′ exonuclease activities. Nucleic Acids Res. 2018, 46, 4164–4175. DOI: 10.1093/nar/gky238 PMID: 29635474
Chaker-Margot, Malik Singh, S.; Vanden Broeck, A.; Miller, L.; Chaker-Margot, M.; Klinge, S. Nucleolar maturation of the human small subunit processome. Science 2021, 373, eabj5338. DOI: 10.1126/science.abj5338 PMID: 34516797
Chaker-Margot, M.; Klinge, S. Assembly and early maturation of large subunit precursors. RNA 2019, 25, 465–471. DOI: 10.1261/rna.069799.118 PMID: 30670483
Bolze, A.; Boisson, B.; Bosch, B.; Antipenko, A.; Bouaziz, M.; Sackstein, P.; Chaker-Margot, M.; Barlogis, V.; Briggs, T.; Colino, E.; Elmore, A. C.; Fischer, A.; Genel, F.; Hewlett, A.; Jedidi, M.; Kelecic, J.; Krüger, R.; Ku, C. L.; Kumararatne, D.; Lefevre-Utile, A.; Loughlin, S.; Mahlaoui, N.; Markus, S.; Garcia, J. M.; Nizon, M.; Oleastro, M.; Pac, M.; Picard, C.; Pollard, A. J.; Rodriguez-Gallego, C.; Thomas, C.; Von Bernuth, H.; Worth, A.; Meyts, I.; Risolino, M.; Selleri, L.; Puel, A.; Klinge, S.; Abel, L.; Casanova, J. L. Incomplete penetrance for isolated congenital asplenia in humans with mutations in translated and untranslated RPSA exons. Proc. Natl. Acad. Sci. U.S.A. 2018, 115, E8007–E8016. DOI: 10.1073/pnas.1805437115 PMID: 30072435
Chaker-Margot, M.* Assembly of the small ribosomal subunit in yeast: Mechanism and regulation. RNA 2018, 24, 881–891. DOI: 10.1261/rna.066985.118 PMID: 29712726
Sanghai, Z. A.; Miller, L.; Molloy, K. R.; Barandun, J.; Hunziker, M.; Chaker-Margot, M.; Wang, J.; Chait, B. T.; Klinge, S. Modular assembly of the nucleolar pre-60S ribosomal subunit. Nature 2018, 556, 126–129. DOI: 10.1038/nature26156 PMID: 29512650
Barandun, J.; Chaker-Margot, M.; Hunziker, M.; Molloy, K. R.; Chait, B. T.; Klinge, S. The complete structure of the small-subunit processome. Nat. Struct. Mol. Biol. 2017, 24, 944–953. DOI: 10.1038/nsmb.3472 PMID: 28945246
Chaker-Margot, M.; Barandun, J.; Hunziker, M.; Klinge, S. Architecture of the yeast small subunit processome. Science 2017, 355, eaal1880. DOI: 10.1126/science.aal1880 PMID: 27980088
Hunziker, M.; Barandun, J.; Petfalski, E.; Tan, D.; Delan-Forino, C.; Molloy, K. R.; Kim, K. H.; Dunn-Davies, H.; Shi, Y.; Chaker-Margot, M.; Chait, B. T.; Walz, T.; Tollervey, D.; Klinge, S. UtpA and UtpB chaperone nascent pre-ribosomal RNA and U3 snoRNA to initiate eukaryotic ribosome assembly. Nat. Commun. 2016, 7, 12090. DOI: 10.1038/ncomms12090 PMID: 27354316
Chaker-Margot, M.; Hunziker, M.; Barandun, J.; Dill, B. D.; Klinge, S. Stage-specific assembly events of the 6-MDa small-subunit processome initiate eukaryotic ribosome biogenesis. Nat. Struct. Mol. Biol. 2015, 22, 920–923. DOI: 10.1038/nsmb.3111 PMID: 26479197
Chakraborty, Debjani Feng, Z.; Chakraborty, D.; Dewell, S. B.; Reddy, B. V.; Brady, S. F. Environmental DNA-encoded antibiotics fasamycins A and B inhibit FabF in type II fatty acid biosynthesis. J. Am. Chem. Soc. 2012, 134, 2981–2987. DOI: 10.1021/ja207662w PMID: 22224500
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†Denotes co-first authors; *Denotes corresponding author.