Weill Cornell Medical College The Rockefeller University Memorial Sloan-Kettering Cancer Center

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Publications

Student publications at the forefront of chemical biology

TPCB students have an exceptional publication record, averaging 5 papers per PhD graduate! This prolific group has published over 350 scientific papers since 2003, in high impact journals including Nature, Science, Journal of the American Chemical Society, Angewandte Chemie, Nature Chemical Biology, ACS Chemical Biology, Chemistry & Biology, Cell, Proceedings of the National Academy of Sciences, and PLoS One. Because of our highly interactive research environment, many of these papers involve multidisciplinary collaborations between TPCB laboratories as well as with other researchers on the Tri-Institutional campuses.

Name Publications
Banerjee, Sourabh Menon, I.; Huber, T.; Sanyal, S.; Banerjee, S.; Barré, P.; Canis, S.; Warren, J. D.; Hwa, J.; Sakmar, T. P.; Menon, A. K. Opsin is a phospholipid flippase. Curr. Biol. 2011, 21, 149–153. DOI: 10.1016/j.cub.2010.12.031 PMID: 21236677
Knepp, A. M.; Grunbeck, A.; Banerjee, S.; Sakmar, T. P.; Huber, T. Direct measurement of thermal stability of expressed CCR5 and stabilization by small molecule ligands. Biochemistry 2011, 50, 502–511. DOI: 10.1021/bi101059w PMID: 21155586
Zaitseva, E.; Saavedra, M.; Banerjee, S.; Sakmar, T. P.; Vogel, R. SEIRA spectroscopy on a membrane receptor monolayer using lipoprotein particles as carriers. Biophys. J. 2010, 99, 2327–2335. DOI: 10.1016/j.bpj.2010.06.054 PMID: 20923668
Banerjee, S.; Huber, T.; Sakmar, T. P. Rapid incorporation of functional rhodopsin into nanoscale apolipoprotein bound bilayer (NABB) particles. J. Mol. Biol. 2008, 377, 1067–1081. DOI: 10.1016/j.jmb.2008.01.066 PMID: 18313692
Banik, Jacob Charlop-Powers, Z.; Banik, J. J.; Owen, J. G.; Craig, J. W.; Brady, S. F. Selective enrichment of environmental DNA libraries for genes encoding nonribosomal peptides and polyketides by phosphopantetheine transferase-dependent complementation of siderophore biosynthesis. ACS Chem. Biol. 2013, 8, 138–143. DOI: 10.1021/cb3004918 PMID: 23072412
Bick, M. J.; Banik, J. J.; Darst, S. A.; Brady, S. F. The 2.7 Å resolution structure of the glycopeptide sulfotransferase Teg14. Acta Crystallogr. D Biol. Crystallogr. 2010, 66, 1278–1286. DOI: 10.1107/S0907444910036681 PMID: 21123867
Banik, J. J.; Craig, J. W.; Calle, P. Y.; Brady, S. F. Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products. J. Am. Chem. Soc. 2010, 132, 15661–15670. DOI: 10.1021/ja105825a PMID: 20945895
Banik, J. J.; Brady, S. F. Recent application of metagenomic approaches toward the discovery of antimicrobials and other bioactive small molecules. Curr. Opin. Microbiol. 2010, 13, 603–609. DOI: 10.1016/j.mib.2010.08.012 PMID: 20884282
Bick, M. J.; Banik, J. J.; Darst, S. A.; Brady, S. F. Crystal structures of the glycopeptide sulfotransferase Teg12 in a complex with the teicoplanin aglycone. Biochemistry 2010, 49, 4159–4168. DOI: 10.1021/bi100150v PMID: 20361791
Banik, J. J.; Brady, S. F. Cloning and characterization of new glycopeptide gene clusters found in an environmental DNA megalibrary. Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 17273–17277. DOI: 10.1073/pnas.0807564105 PMID: 18987322
Bauer, Renato Wenderski, T. A.; Stratton, C. F.; Bauer, R. A.; Kopp, F.; Tan, D. S. Principal component analysis as a tool for library design: a case study investigating natural products, brand-name drugs, natural product-like libraries, and drug-like libraries. Methods Mol. Biol. 2015, 1263, 225–242. DOI: 10.1007/978-1-4939-2269-7_18 PMID: 25618349
Bauer, R. A.; Wenderski, T. A.; Tan, D. S. Biomimetic diversity-oriented synthesis of benzannulated medium rings via ring expansion. Nat. Chem. Biol. 2012, 9, 21–29. DOI: 10.1038/nchembio.1130 PMID: 23160003
Moura-Letts, G.; DiBlasi, C. M.; Bauer, R. A.; Tan, D. S. Solid-phase synthesis and chemical space analysis of a 190-membered alkaloid/terpenoid-like library. Proc. Natl. Acad. Sci. U.S.A. 2011, 108, 6745–6750. DOI: 10.1073/pnas.1015268108 PMID: 21451137
Bauer, R. A.; DiBlasi, C. M.; Tan, D. S. The tert-butylsulfinamide lynchpin in transition-metal-mediated multiscaffold library synthesis. Org. Lett. 2010, 12, 2084–2087. DOI: 10.1021/ol100574y PMID: 20356070
Bauer, R. A.; Wurst, J. M.; Tan, D. S. Expanding the range of ‘druggable’ targets with natural product-based libraries: an academic perspective. Curr. Opin. Chem. Biol. 2010, 14, 308–314. DOI: 10.1016/j.cbpa.2010.02.001 PMID: 20202892
Blum, Gil Linscott, J. A.; Kapilashrami, K.; Wang, Z.; Senevirathne, C.; Bothwell, I. R.; Blum, G.; Luo, M. Kinetic isotope effects reveal early transition state of protein lysine methyltransferase SET8. Proc. Natl. Acad. Sci. U.S.A. 2016, 113, E8369-E8378. DOI: 10.1073/pnas.1609032114 PMID: 27940912
LaFave, L. M.; Béguelin, W.; Koche, R.; Teater, M.; Spitzer, B.; Chramiec, A.; Papalexi, E.; Keller, M. D.; Hricik, T.; Konstantinoff, K.; Micol, J. B.; Durham, B.; Knutson, S. K.; Campbell, J. E.; Blum, G.; Shi, X.; Doud, E. H.; Krivtsov, A. V.; Chung, Y. R.; Khodos, I.; de Stanchina, E.; Ouerfelli, O.; Adusumilli, P. S.; Thomas, P. M.; Kelleher, N. L.; Luo, M.; Keilhack, H.; Abdel-Wahab, O.; Melnick, A.; Armstrong, S. A.; Levine, R. L. Loss of BAP1 function leads to EZH2-dependent transformation. Nat. Med. 2015, 21, 1344–1349. DOI: 10.1038/nm.3947 PMID: 26437366
Blum, G.; Ibáñez, G.; Rao, X.; Shum, D.; Radu, C.; Djaballah, H.; Rice, J. C.; Luo, M. Small-molecule inhibitors of SETD8 with cellular activity. ACS Chem. Biol. 2014, 9, 2471–2478. DOI: 10.1021/cb500515r PMID: 25137013
Guo, H.; Wang, R.; Zheng, W.; Chen, Y.; Blum, G.; Deng, H.; Luo, M. Profiling substrates of protein arginine N-methyltransferase 3 with S-adenosyl-L-methionine analogues. ACS Chem. Biol. 2014, 9, 476–484. DOI: 10.1021/cb4008259 PMID: 24320160
Islam, K.; Chen, Y.; Wu, H.; Bothwell, I. R.; Blum, G. J.; Zeng, H.; Dong, A.; Zheng, W.; Min, J.; Deng, H.; Luo, M. Defining efficient enzyme-cofactor pairs for bioorthogonal profiling of protein methylation. Proc. Natl. Acad. Sci. U.S.A. 2013, 110, 16778–16783. DOI: 10.1073/pnas.1216365110 PMID: 24082136
Blum, G.; Bothwell, I. R.; Islam, K.; Luo, M. Profiling protein methylation with cofactor analog containing terminal alkyne functionality. Curr. Protoc. Chem. Biol. 2013, 5, 67–88. DOI: 10.1002/9780470559277.ch120241 PMID: 23788324
Blum, G.; Islam, K.; Luo, M. Bioorthogonal profiling of protein methylation (BPPM) using an azido analog of S-adenosyl-L-methionine. Curr. Protoc. Chem. Biol. 2013, 5, 45–66. DOI: 10.1002/9780470559277.ch120241 PMID: 23667794
Wang, R.; Islam, K.; Liu, Y.; Zheng, W.; Tang, H.; Lailler, N.; Blum, G.; Deng, H.; Luo, M. Profiling genome-wide chromatin methylation with engineered posttranslation apparatus within living cells. J. Am. Chem. Soc. 2013, 135, 1048–1056. DOI: 10.1021/ja309412s PMID: 23244065
Zheng, W.; Ibáñez, G.; Wu, H.; Blum, G.; Zeng, H.; Dong, A.; Li, F.; Hajian, T.; Allali-Hassani, A.; Amaya, M. F.; Siarheyeva, A.; Yu, W.; Brown, P. J.; Schapira, M.; Vedadi, M.; Min, J.; Luo, M. Sinefungin derivatives as inhibitors and structure probes of protein lysine methyltransferase SETD2. J. Am. Chem. Soc. 2012, 134, 18004–18014. DOI: 10.1021/ja307060p PMID: 23043551
Bothwell, I. R.; Islam, K.; Chen, Y.; Zheng, W.; Blum, G.; Deng, H.; Luo, M. Se-adenosyl-L-selenomethionine cofactor analogue as a reporter of protein methylation. J. Am. Chem. Soc. 2012, 134, 14905–14912. DOI: 10.1021/ja304782r PMID: 22917021
Ibanez, G.; Shum, D.; Blum, G.; Bhinder, B.; Radu, C.; Antczak, C.; Luo, M.; Djaballah, H. A high throughput scintillation proximity imaging assay for protein methyltransferases. Comb. Chem. High Throughput Screen. 2012, 15, 359–371. DOI: 10.2174/138620712800194468 PMID: 22256970
Wang, R.; Ibáñez, G.; Islam, K.; Zheng, W.; Blum, G.; Sengelaub, C.; Luo, M. Formulating a fluorogenic assay to evaluate S-adenosyl-L-methionine analogues as protein methyltransferase cofactors. Mol Biosyst 2011, 7, 2970–2981. DOI: 10.1039/c1mb05230f PMID: 21866297
Bose, Neelanjan Narayan, A.; Venkatachalam, V.; Durak, O.; Reilly, D. K.; Bose, N.; Schroeder, F. C.; Samuel, A. D.; Srinivasan, J.; Sternberg, P. W. Contrasting responses within a single neuron class enable sex-specific attraction in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U.S.A. 2016, 113, E1392–E1401. DOI: 10.1073/pnas.1600786113 PMID: 26903633
Chaudhuri, J.; Bose, N.; Tandonnet, S.; Adams, S.; Zuco, G.; Kache, V.; Parihar, M.; von Reuss, S. H.; Schroeder, F. C.; Pires-daSilva, A. Mating dynamics in a nematode with three sexes and its evolutionary implications. Sci. Rep. 2015, 5, 17676. DOI: 10.1038/srep17676 PMID: 26631423
Yim, J. J.; Bose, N.; Meyer, J. M.; Sommer, R. J.; Schroeder, F. C. Nematode signaling molecules derived from multimodular assembly of primary metabolic building blocks. Org. Lett. 2015, 17, 1648–1651. DOI: 10.1021/acs.orglett.5b00329 PMID: 25782998
Zugasti, O.; Bose, N.; Squiban, B.; Belougne, J.; Kurz, C. L.; Schroeder, F. C.; Pujol, N.; Ewbank, J. J. Activation of a G protein-coupled receptor by its endogenous ligand triggers the innate immune response of Caenorhabditis elegans. Nat. Immunol. 2014, 15, 833–838. DOI: 10.1038/ni.2957 PMID: 25086774
Bose, N.; Meyer, J. M.; Yim, J. J.; Mayer, M. G.; Markov, G. V.; Ogawa, A.; Schroeder, F. C.; Sommer, R. J. Natural variation in dauer pheromone production and sensing supports intraspecific competition in nematodes. Curr. Biol. 2014, 24, 1536–1541. DOI: 10.1016/j.cub.2014.05.045 PMID: 24980503
Mahanti, P.; Bose, N.; Bethke, A.; Judkins, J. C.; Wollam, J.; Dumas, K. J.; Zimmerman, A. M.; Campbell, S. L.; Hu, P. J.; Antebi, A.; Schroeder, F. C. Comparative metabolomics reveals endogenous ligands of DAF-12, a nuclear hormone receptor, regulating C. elegans development and lifespan. Cell Metab. 2014, 19, 73–83. DOI: 10.1016/j.cmet.2013.11.024 PMID: 24411940
Artyukhin, A. B.; Yim, J. J.; Srinivasan, J.; Izrayelit, Y.; Bose, N.; von Reuss, S. H.; Jo, Y.; Jordan, J. M.; Baugh, L. R.; Cheong, M.; Sternberg, P. W.; Avery, L.; Schroeder, F. C. Succinylated octopamine ascarosides and a new pathway of biogenic amine metabolism in Caenorhabditis elegans. J. Biol. Chem. 2013, 288, 18778–18783. DOI: 10.1074/jbc.C113.477000 PMID: 23689506
Izrayelit, Y.; Robinette, S. L.; Bose, N.; von Reuss, S. H.; Schroeder, F. C. 2D NMR-based metabolomics uncovers interactions between conserved biochemical pathways in the model organism Caenorhabditis elegans. ACS Chem. Biol. 2013, 8, 314–319. DOI: 10.1021/cb3004644 PMID: 23163760
Bose, N.; Ogawa, A.; von Reuss, S. H.; Yim, J. J.; Ragsdale, E. J.; Sommer, R. J.; Schroeder, F. C. Complex small-molecule architectures regulate phenotypic plasticity in a nematode. Angew. Chem. Int. Ed. Engl. 2012, 51, 12438–12443. DOI: 10.1002/anie.201206797 PMID: 23161728
Srinivasan, J.; von Reuss, S. H.; Bose, N.; Zaslaver, A.; Mahanti, P.; Ho, M. C.; O’Doherty, O. G.; Edison, A. S.; Sternberg, P. W.; Schroeder, F. C. A modular library of small molecule signals regulates social behaviors in Caenorhabditis elegans. PLoS Biol. 2012, 10, e1001237. DOI: 10.1371/journal.pbio.1001237 PMID: 22253572
von Reuss, S. H.; Bose, N.; Srinivasan, J.; Yim, J. J.; Judkins, J. C.; Sternberg, P. W.; Schroeder, F. C. Comparative metabolomics reveals biogenesis of ascarosides, a modular library of small-molecule signals in C. elegans. J. Am. Chem. Soc. 2012, 134, 1817–1824. DOI: 10.1021/ja210202y PMID: 22239548
Bothwell, Ian Linscott, J. A.; Kapilashrami, K.; Wang, Z.; Senevirathne, C.; Bothwell, I. R.; Blum, G.; Luo, M. Kinetic isotope effects reveal early transition state of protein lysine methyltransferase SET8. Proc. Natl. Acad. Sci. U.S.A. 2016, 113, E8369-E8378. DOI: 10.1073/pnas.1609032114 PMID: 27940912
Bothwell, I. R.; Luo, M. Large-scale, protection-free synthesis of Se-adenosyl-L-selenomethionine analogues and their application as cofactor surrogates of methyltransferases. Org. Lett. 2014, 16, 3056–3059. DOI: 10.1021/ol501169y PMID: 24852128
Islam, K.; Chen, Y.; Wu, H.; Bothwell, I. R.; Blum, G. J.; Zeng, H.; Dong, A.; Zheng, W.; Min, J.; Deng, H.; Luo, M. Defining efficient enzyme-cofactor pairs for bioorthogonal profiling of protein methylation. Proc. Natl. Acad. Sci. U.S.A. 2013, 110, 16778–16783. DOI: 10.1073/pnas.1216365110 PMID: 24082136
Winter, J. M.; Chiou, G.; Bothwell, I. R.; Xu, W.; Garg, N. K.; Luo, M.; Tang, Y. Expanding the structural diversity of polyketides by exploring the cofactor tolerance of an inline methyltransferase domain. Org. Lett. 2013, 15, 3774–3777. DOI: 10.1021/ol401723h PMID: 23837609
Blum, G.; Bothwell, I. R.; Islam, K.; Luo, M. Profiling protein methylation with cofactor analog containing terminal alkyne functionality. Curr. Protoc. Chem. Biol. 2013, 5, 67–88. DOI: 10.1002/9780470559277.ch120241 PMID: 23788324
Bothwell, I. R.; Islam, K.; Chen, Y.; Zheng, W.; Blum, G.; Deng, H.; Luo, M. Se-adenosyl-L-selenomethionine cofactor analogue as a reporter of protein methylation. J. Am. Chem. Soc. 2012, 134, 14905–14912. DOI: 10.1021/ja304782r PMID: 22917021
Islam, K.; Bothwell, I.; Chen, Y.; Sengelaub, C.; Wang, R.; Deng, H.; Luo, M. Bioorthogonal profiling of protein methylation using azido derivative of S-adenosyl-L-methionine. J. Am. Chem. Soc. 2012, 134, 5909–5915. DOI: 10.1021/ja2118333 PMID: 22404544
Chaker-Margot, Malik Chaker-Margot, M.; Barandun, J.; Hunziker, M.; Klinge, S. Architecture of the yeast small subunit processome. Science 2017, 355, eaal1880. DOI: 10.1126/science.aal1880 PMID: 27980088
Hunziker, M.; Barandun, J.; Petfalski, E.; Tan, D.; Delan-Forino, C.; Molloy, K. R.; Kim, K. H.; Dunn-Davies, H.; Shi, Y.; Chaker-Margot, M.; Chait, B. T.; Walz, T.; Tollervey, D.; Klinge, S. UtpA and UtpB chaperone nascent pre-ribosomal RNA and U3 snoRNA to initiate eukaryotic ribosome assembly. Nat. Commun. 2016, 7, 12090. DOI: 10.1038/ncomms12090 PMID: 27354316
Chaker-Margot, M.; Hunziker, M.; Barandun, J.; Dill, B. D.; Klinge, S. Stage-specific assembly events of the 6-MDa small-subunit processome initiate eukaryotic ribosome biogenesis. Nat. Struct. Mol. Biol. 2015, 22, 920–923. DOI: 10.1038/nsmb.3111 PMID: 26479197
Chakraborty, Debjani Feng, Z.; Chakraborty, D.; Dewell, S. B.; Reddy, B. V.; Brady, S. F. Environmental DNA-encoded antibiotics fasamycins A and B inhibit FabF in type II fatty acid biosynthesis. J. Am. Chem. Soc. 2012, 134, 2981–2987. DOI: 10.1021/ja207662w PMID: 22224500
Chakraborty, D.; Islam, K.; Luo, M. Facile synthesis and altered ionization efficiency of diverse Nε-alkyllysine-containing peptides. Chem. Commun. (Camb.) 2012, 48, 1514–1516. DOI: 10.1039/c1cc14711k PMID: 21959946
Chakravarty, Anupam Chakravarty, A. K.; Smith, P.; Jalan, R.; Shuman, S. Structure, mechanism, and specificity of a eukaryal tRNA restriction enzyme involved in self-nonself discrimination. Cell Rep 2014, 7, 339–347. DOI: 10.1016/j.celrep.2014.03.034 PMID: 24726365
Das, U.; Chakravarty, A. K.; Remus, B. S.; Shuman, S. Rewriting the rules for end joining via enzymatic splicing of DNA 3´-PO4 and 5´-OH ends. Proc. Natl. Acad. Sci. U.S.A. 2013, 110, 20437–20442. DOI: 10.1073/pnas.1314289110 PMID: 24218597
Chakravarty, A. K.; Shuman, S. The sequential 2´,3´-cyclic phosphodiesterase and 3´-phosphate/5´-OH ligation steps of the RtcB RNA splicing pathway are GTP-dependent. Nucleic Acids Res. 2012, 40, 8558–8567. DOI: 10.1093/nar/gks558 PMID: 22730297
Chakravarty, A. K.; Subbotin, R.; Chait, B. T.; Shuman, S. RNA ligase RtcB splices 3´-phosphate and 5´-OH ends via covalent RtcB-(histidinyl)-GMP and polynucleotide-(3´)pp(5´)G intermediates. Proc. Natl. Acad. Sci. U.S.A. 2012, 109, 6072–6077. DOI: 10.1073/pnas.1201207109 PMID: 22474365
Chakravarty, A. K.; Smith, P.; Shuman, S. Structures of RNA 3´-phosphate cyclase bound to ATP reveal the mechanism of nucleotidyl transfer and metal-assisted catalysis. Proc. Natl. Acad. Sci. U.S.A. 2011, 108, 21034–21039. DOI: 10.1073/pnas.1115560108 PMID: 22167800
Tanaka, N.; Chakravarty, A. K.; Maughan, B.; Shuman, S. Novel mechanism of RNA repair by RtcB via sequential 2´,3´-cyclic phosphodiesterase and 3´-phosphate/5´-hydroxyl ligation reactions. J. Biol. Chem. 2011, 286, 43134–43143. DOI: 10.1074/jbc.M111.302133 PMID: 22045815
Jain, R.; Poulos, M. G.; Gros, J.; Chakravarty, A. K.; Shuman, S. Substrate specificity and mutational analysis of Kluyveromyces lactis gamma-toxin, a eukaryal tRNA anticodon nuclease. RNA 2011, 17, 1336–1343. DOI: 10.1261/rna.2722711 PMID: 21610213
Chakravarty, A. K.; Shuman, S. RNA 3´-phosphate cyclase (RtcA) catalyzes ligase-like adenylylation of DNA and RNA 5´-monophosphate ends. J. Biol. Chem. 2011, 286, 4117–4122. DOI: 10.1074/jbc.M110.196766 PMID: 21098490
Chao, Xingjuan Chao, X.; Muff, T. J.; Park, S. Y.; Zhang, S.; Pollard, A. M.; Ordal, G. W.; Bilwes, A. M.; Crane, B. R. A receptor-modifying deamidase in complex with a signaling phosphatase reveals reciprocal regulation. Cell 2006, 124, 561–571. DOI: 10.1016/j.cell.2005.11.046 PMID: 16469702
Park, S. Y.; Chao, X.; Gonzalez-Bonet, G.; Beel, B. D.; Bilwes, A. M.; Crane, B. R. Structure and function of an unusual family of protein phosphatases: the bacterial chemotaxis proteins CheC and CheX. Mol. Cell 2004, 16, 563–574. DOI: 10.1016/j.molcel.2004.10.018 PMID: 15546616
Charron, Guillaume Charron, G.; Li, M. M.; MacDonald, M. R.; Hang, H. C. Prenylome profiling reveals S-farnesylation is crucial for membrane targeting and antiviral activity of ZAP long-isoform. Proc. Natl. Acad. Sci. U.S.A. 2013, 110, 11085–11090. DOI: 10.1073/pnas.1302564110 PMID: 23776219
Jiang, H.; Khan, S.; Wang, Y.; Charron, G.; He, B.; Sebastian, C.; Du, J.; Kim, R.; Ge, E.; Mostoslavsky, R.; Hang, H. C.; Hao, Q.; Lin, H. SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine. Nature 2013, 496, 110–113. DOI: 10.1038/nature12038 PMID: 23552949
Hicks, S. W.; Charron, G.; Hang, H. C.; Galán, J. E. Subcellular targeting of Salmonella virulence proteins by host-mediated S-palmitoylation. Cell Host Microbe 2011, 10, 9–20. DOI: 10.1016/j.chom.2011.06.003 PMID: 21767808
Hang, H. C.; Wilson, J. P.; Charron, G. Bioorthogonal chemical reporters for analyzing protein lipidation and lipid trafficking. Acc. Chem. Res. 2011, 44, 699–708. DOI: 10.1021/ar200063v PMID: 21675729
Yount, J. S.; Charron, G.; Hang, H. C. Bioorthogonal proteomics of 15-hexadecynyloxyacetic acid chemical reporter reveals preferential targeting of fatty acid modified proteins and biosynthetic enzymes. Bioorg. Med. Chem. 2012, 20, 650–654. DOI: 10.1016/j.bmc.2011.03.062 PMID: 21524915
Zuckerman, D. M.; Hicks, S. W.; Charron, G.; Hang, H. C.; Machamer, C. E. Differential regulation of two palmitoylation sites in the cytoplasmic tail of the beta1-adrenergic receptor. J. Biol. Chem. 2011, 286, 19014–19023. DOI: 10.1074/jbc.M110.189977 PMID: 21464135
Charron, G.; Tsou, L. K.; Maguire, W.; Yount, J. S.; Hang, H. C. Alkynyl-farnesol reporters for detection of protein S-prenylation in cells. Mol Biosyst 2010, 7, 67–73. DOI: 10.1039/c0mb00183j PMID: 21107478
Yang, Y. Y.; Grammel, M.; Raghavan, A. S.; Charron, G.; Hang, H. C. Comparative analysis of cleavable azobenzene-based affinity tags for bioorthogonal chemical proteomics. Chem. Biol. 2010, 17, 1212–1222. DOI: 10.1016/j.chembiol.2010.09.012 PMID: 21095571
Wilson, J. P.; Raghavan, A. S.; Yang, Y. Y.; Charron, G.; Hang, H. C. Proteomic analysis of fatty-acylated proteins in mammalian cells with chemical reporters reveals S-acylation of histone H3 variants. Mol. Cell Proteomics 2011, 10, M110.001198. DOI: 10.1074/mcp.M110.001198 PMID: 21076176
Ivanov, S. S.; Charron, G.; Hang, H. C.; Roy, C. R. Lipidation by the host prenyltransferase machinery facilitates membrane localization of Legionella pneumophila effector proteins. J. Biol. Chem. 2010, 285, 34686–34698. DOI: 10.1074/jbc.M110.170746 PMID: 20813839
Yount, J. S.; Moltedo, B.; Yang, Y. Y.; Charron, G.; Moran, T. M.; López, C. B.; Hang, H. C. Palmitoylome profiling reveals S-palmitoylation-dependent antiviral activity of IFITM3. Nat. Chem. Biol. 2010, 6, 610–614. DOI: 10.1038/nchembio.405 PMID: 20601941
Zhang, M. M.; Tsou, L. K.; Charron, G.; Raghavan, A. S.; Hang, H. C. Tandem fluorescence imaging of dynamic S-acylation and protein turnover. Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 8627–8632. DOI: 10.1073/pnas.0912306107 PMID: 20421494
Rangan, K. J.; Yang, Y. Y.; Charron, G.; Hang, H. C. Rapid visualization and large-scale profiling of bacterial lipoproteins with chemical reporters. J. Am. Chem. Soc. 2010, 132, 10628–10629. DOI: 10.1021/ja101387b PMID: 20230003
Charron, G.; Wilson, J.; Hang, H. C. Chemical tools for understanding protein lipidation in eukaryotes. Curr. Opin. Chem. Biol. 2009, 13, 382–391. DOI: 10.1016/j.cbpa.2009.07.010 PMID: 19699139
Charron, G.; Zhang, M. M.; Yount, J. S.; Wilson, J.; Raghavan, A. S.; Shamir, E.; Hang, H. C. Robust fluorescent detection of protein fatty-acylation with chemical reporters. J. Am. Chem. Soc. 2009, 131, 4967–4975. DOI: 10.1021/ja810122f PMID: 19281244
Raghavan, A.; Charron, G.; Flexner, J.; Hang, H. C. Chemical probes for profiling fatty acid-associated proteins in living cells. Bioorg. Med. Chem. Lett. 2008, 18, 5982–5986. DOI: 10.1016/j.bmcl.2008.09.083 PMID: 18929483
Chen, Zhen Kawashima, S. A.; Chen, Z.; Aoi, Y.; Patgiri, A.; Kobayashi, Y.; Nurse, P.; Kapoor, T. M. Potent, reversible, and specific chemical inhibitors of eukaryotic ribosome biogenesis. Cell 2016, 167, 512-524. DOI: 10.1016/j.cell.2016.08.070 PMID: 27667686 († = co-first authors)
Chiang, Ethan Veatch, S. L.; Chiang, E. N.; Sengupta, P.; Holowka, D. A.; Baird, B. A. Quantitative nanoscale analysis of IgE-FcεRI clustering and coupling to early signaling proteins. J Phys Chem B 2012, 116, 6923–6935. DOI: 10.1021/jp300197p PMID: 22397623
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