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TPCB Faculty

Yueming Li, PhD

Memorial Sloan-Kettering Cancer Center

Education

PhD, 1992, University of California, Berkeley

MS, 1984, Chinese Academy of Sciences

BS, 1982, Shanxi Agriculture University

Research Topics

  • Bioactive Small Molecules
    • High-throughput screening assays
    • Chemical probe development
  • Macromolecular Structure and Function
    • Enzymology
    • Mass spectrometry
  • Chemical Cell Biology
    • Chemical genetics
    • Cellular imaging
    • Proteomics
    • Activity-based protein profiling

Therapeutic Areas

  • Cancer
  • Neuroscience

photoThe main interest of the Li lab is to study regulated intramembrane proteolysis (RIP) and signal transduction. RIP has emerged as a novel-signaling paradigm in the new millennium. Intramembrane cleavage proteases not only serve as highly effective post-translational regulators of protein function but also represent a unique class of enzymes that catalyze substrate hydrolysis within transmembrane domains. Two intramembrane proteases — gamma-secretase and Rhomboid-mediated intramembrane serine protease are under investigation in our lab, utilizing the powerful tools of molecular biology, protein chemistry, chemistry, and proteomics.

Read more about Prof. Li’s research on the Sloan-Kettering website

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