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TPCB Faculty

Pengbo Zhou, PhD

Weill Cornell Medical College

Education

PhD, 1993, University of Michigan Medical School

BS, 1987, Peking University

Research Topics

  • Bioactive Small Molecules
    • High-throughput screening assays
    • Chemical probe development
    • Rational drug design
  • Macromolecular Structure and Function
    • Enzymology
    • Mass spectometry
  • Chemical Cell Biology
    • Chemcial genetics
    • Proteomics
  • Biotechnology
    • Protein engineering

Therapeutic Areas

  • Cancer
  • Neuroscience

photoResearch in the Zhou lab focuses on dissecting the physiological and pathological functions of ubiquitin-dependent proteolysis, and developing chemical inhibitors of Cullin-based ubiquitin ligases as novel therapeutic agents. With the extensive interrogation of kinases and G protein-coupled receptors, ubiquitin ligases are now considered as the next frontier for drug discovery. The Zhou laboratory employs a combination of chemical biology, biochemistry, cell and molecular biology, mouse genetics, and human pathobiology approaches to interrogate the ubiquitin ligases as potential targets for therapeutic intervention.

Read more about Prof. Zhou’s research on the Weill Cornell website

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