TPCB Faculty
Xiaolan Zhao, PhD
Memorial Sloan Kettering Cancer Center
Education
PhD, 2000, Columbia University
MS, 1994, Peking University
BS, 1991, Peking University
Research Topics
- Macromolecular Structure and Function
- Enzymology
- Mass spectrometry
- Cryo-electron microscopy
- Single molecule methods
- Chemical Cell Biology
- Chemical genetics
- Cellular imaging
- Proteomics
- Activity-based protein profiling
Therapeutic Areas
- Cancer
- Microbiology
- Virology
Genome replication, repair, and stress response, collectively called the 3Rs, support genome stability and faithful genetic inheritance. Proteins involved in the 3Rs are genome guardians that prevent a broad spectrum of diseases, ranging from cancers, immunological and neurodegenerative diseases, to developmental disorders such as diabetes and premature aging. The Zhao lab investigates 3R mechanisms, 3R protein functions and structures, and their links to human disease. We have established cutting-edge and multi-disciplinary approaches, including chemical biology, genetic, biochemical, structural, single molecule, and genomic strategies. Our broad research scope and approaches provide lab members ample opportunities to discover new biological principles in a supportive and collaborative environment.
Read more about Prof. Zhao’s research on the Sloan Kettering website