TPCB Faculty
Yueming Li, PhD
Memorial Sloan Kettering Cancer Center
Education
PhD, 1992, University of California, Berkeley
MS, 1984, Chinese Academy of Sciences
BS, 1982, Shanxi Agriculture University
Research Topics
- Bioactive Small Molecules
- High-throughput screening assays
- Chemical probe development
- Macromolecular Structure and Function
- Enzymology
- Mass spectrometry
- Chemical Cell Biology
- Chemical genetics
- Cellular imaging
- Proteomics
- Activity-based protein profiling
Therapeutic Areas
- Cancer
- Neuroscience
The main interest of the Li lab is to study regulated intramembrane proteolysis (RIP) and signal transduction. RIP has emerged as a novel-signaling paradigm in the new millennium. Intramembrane cleavage proteases not only serve as highly effective post-translational regulators of protein function but also represent a unique class of enzymes that catalyze substrate hydrolysis within transmembrane domains. Two intramembrane proteases — gamma-secretase and Rhomboid-mediated intramembrane serine protease are under investigation in our lab, utilizing the powerful tools of molecular biology, protein chemistry, chemistry, and proteomics.
Read more about Prof. Li’s research on the Sloan Kettering website