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TPCB is now accepting applications for admission to the entering class of 2022! Please note that the deadline for receipt of all application materials, including letters of recommendation, is December 1, 2021. Selected students will be invited to attend our Open House event on January 17–19, 2022. [Start your application today!]

TPCB is excited to welcome two new faculty to the program, bringing exciting new research opportunities! Prof. Melinda Diver at MSK is investigating the molecular basis for pain sensation. Prof. Jacob Geri at Weill Cornell is developing new optically-controlled proximity labeling technologies to study protein interactions. [more]

Our Diversity is Our Strength. TPCB has a long-standing commitment to promoting diversity and inclusion at all levels in science. Our outstanding students come from many different backgrounds and the program has zero tolerance for racism or discrimination in any form. We have taken numerous recent efforts to promote these principles. [more].

TPCB faculty member Prof. Katya Vinogradova has been named to the Chemical & Engineering News Talented 12! This list recognizes talented young scientists who are taking risks in the early stages of their careers. Prof. Vinogradova’s research uses chemical proteomics to investigate the immune system. [more]

TPCB congratulates our 2021 graduates! This exceptional group of 13 students successfully completed their PhD training in the midst of the COVID-19 pandemic. They presented their thesis defenses online, surrounded virtually by colleagues, friends, and family. We wish them all the best as they continue onto the next stages of their careers! [more]

Congratulations to Prof. Luciano Marraffini, who has been elected a Member of the American Academy of Arts and Sciences! Election to the Academy is one of the most significant honors one can receive and recognizes Prof. Marraffini’s seminal research on the CRISPR-Cas system that is used in gene editing. [more]

TPCB was pleased to partner with the New York Academy of Sciences to present the annual NYAS Chemical Biology Symposium on May 20, 2021. This event featured lectures by Prof. Matthew Bogyo (Stanford) and Prof. Catherine Grimes (Delaware) as well as talks and posters by students, including TPCB’s Didar Ciftci and Nicholas Prescott!

In a new paper eLife, a collaborative team led by TPCB student Lin Mei and Prof. Gregory Alushin at Rockefeller have uncovered fundamental new insights into the molecular mechanism by which cells detect mechanical signals from their environment, in which tension on the cytoskeletal protein actin leads to stronger binding of α-catenin. [more]

TPCB is excited to welcome three new faculty to the program! Prof. Heeseon An at and Prof. Viviana Risca and Prof. Ekaterina Vinogradova at Rockefeller bring exciting new research opportunities in using chemical tools to study cellular quality control, chromatin architecture, and immune cell function. [more]

Congratulations to TPCB student Sahana Rao, who has received a Kravis Women in Science Endeavor Graduate Fellowship, Prof. Daniel Heller, who was honored with the Weill Cornell Outstanding Teaching and Mentoring Award, and Prof. Alex Kentsis, who was recognized with the MSK Boyer Award for Clinical Research! [more]

TPCB congratulates faculty member Prof. Christopher Lima at MSK on his election to the National Academy of Sciences. Academy membership is considered one of the highest honors in science and recognizes Prof. Lima’s distinguished achievements in studying the structural biology and biochemistry of ubiquitin conjugation and the RNA exosome. [more]

TPCB student Fangyu Liu and colleagues in the lab of Prof. Jue Chen at Rockefeller have determined the structures of two drugs that potentiate the function of the CFTR ion channel, which is mutated in cystic fibrosis. The work paves the way for efforts in rational drug design and was published in the journal Science. [more]

Alumni Profile: TPCB alumni Dr. Renato Bauer and Dr. Jacqueline Wurst discuss the flexibility of the graduate program, the unique opportunities in the Tri-Institutional research environment, and how their training in chemistry prepared them for their current careers in the pharmaceutical industry at Eli Lilly. [more]

Student Profile: TPCB student Chaya Stern describes her non-traditional path to graduate school, where she is now working in Prof. John Chodera’s computational chemistry lab at Sloan Kettering as an NSF Graduate Research Fellow. She also discusses the support she has received from TPCB as a parent. [more]

Alumni Profile: TPCB alumna Prof. Niroshika Keppetipola discusses her training experience with mentor Prof. Stewart Shuman and how it prepared her for an independent academic career. Now a faculty member at Cal State Fullerton, her lab studies post-translational regulation of RNA binding proteins in alternative splicing. [more]

Faculty Profile: TPCB faculty member Prof. Yael David is a new faculty member at Sloan Kettering. She describe her lab’s approach using protein engineering to study epigenetic regulation and its correlation with disease states. She also discusses her approach to mentoring and her experiences as a woman in science. [more]

Alumni Profile: TPCB alumna Dr. Amy Grunbeck Perea developed photoactivatable probes to study G protein-coupled receptors with Prof. Tom Sakmar. After graduating with 9 papers on her CV, she did a postdoc fellowship at Genzyme, then joined Abcam, a biotech company in Cambridge, developing new tools for protein analysis. [more]

Faculty Profile: TPCB faculty member Prof. Jue Chen is an HHMI Investigator who studies the structure and function of molecular pumps called ABC transporters that are involved in many important biological processes. She discusses the recent cryo-EM ‘resolution revolution’ and her personalized approach to mentoring her students. [more]