TPCB Faculty
Michael Rout, PhD
Rockefeller University
Education
PhD, 1990, University of Cambridge
MA, 1990, University of Cambridge
BS, 1986, University of Cambridge
Research Topics
- Macromolecular Structure and Function
- X-ray crystallography
- NMR spectroscopy
- Mass spectrometry
- Cryo-electron microscopy
- Single molecule methods
- Chemical Cell Biology
- Cellular imaging
- Proteomics
- Biotechnology
- Protein engineering
- Computational Chemistry
- Protein modeling
Therapeutic Areas
- Cancer
- Immunology
- Virology
The Rout lab studies nuclear pore complexes (NPCs), which provide the only known sites for nucleocytoplasmic exchange and are also involved in key steps of genetic regulation. Using a variety of techniques, we are determining the structure and mechanisms of the NPC, in order to understand how the NPC functions as a transporter and regulates nuclear processes. We have leveraged techniques developed during these investigations into general tools and reagents for interactomic investigations of cellular systems. Though our collaborative center, the National Center for Dynamic Interactome Research, we train and disseminate these techniques to the biomedical community.
Read more about Prof. Rout’s research on the Rockefeller website