TPCB Faculty
Christopher Lima, PhD
Memorial Sloan Kettering Cancer Center
Education
PhD, 1994, Northwestern University
BA, 1989, The Ohio State University
Awards
HHMI Investigator
Research Topics
- Macromolecular Structure and Function
- Cryo-electron microscopy
- Enzymology
- X-ray crystallography
The Lima lab studies the structural, biochemical, and functional basis for macromolecules involved in post-translational protein modification by SUMO, an ubiquitin-like protein modifier, and pathways that contribute to co-transcriptional RNA maturation and post-transcriptional RNA decay. In addition to our structural studies, our main areas of interest focus on how these pathways contribute to signaling, cell cycle control, nuclear localization, and control of RNA metabolism. We are particularly interested in learning how these pathways contribute to cell growth and disease.
Read more about Prof. Lima’s research on the Sloan Kettering website