TPCB Faculty
Samie Jaffrey, MD, PhD
Weill Cornell Medical College
Education
MD, 1999, The Johns Hopkins University School of Medicine PhD, 1999, The Johns Hopkins University School of Medicine BS, 1992, Massachusetts Institute of Technology
Research Topics
- Bioactive Small Molecules
- High-throughput screening assays
- Chemical probe development
- Macromolecular Structure and Function
- Enzymology
- Mass spectrometry
- Chemical Cell Biology
- Chemical genetics
- Cellular imaging
- Proteomics
- Metabolomics
Therapeutic Areas
- Cancer
- Diabetes
- Neuroscience
Research in the Jaffrey lab focuses on the function of RNA modifications in gene regulation and using synthetic and chemical biology approaches to develop RNAs with novel functions. We created a class of RNA mimics of green fluorescent protein, most notably Spinach, which comprises a specific RNA aptamer and a small molecule dye whose fluorescence is switched on upon binding the RNA. We are developing novel RNA-fluorophore complexes with novel spectral properties for studying RNA trafficking and imaging RNA processing events in living cells.
Read more about Prof. Jaffrey’s research on the Weill Cornell website