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TPCB is a leading PhD graduate program in chemical biology, offered jointly by three premier institutions in New York City. We provide an unparalleled combination of world-class faculty, state-of-the-art facilities, and collaborative research opportunities to the next generation of scientific leaders working at the interface of chemistry, biology, and medicine.
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The 13th Annual Tri-Institutional Chemical Biology Symposium, was held on September 7, 2017, featuring faculty keynote presentations by Profs. Helen Blackwell, Daniel Heller, Dorothee Kern, and Kevan Shokat. TPCB students John Zinder, Shi Chen, and Zhen Chen also presented their latest research. [more]
TPCB student Zhen Chen and colleagues in the lab of Prof. Tarun Kapoor at Rockefeller have discovered the “Rbins” as novel small-molecule inhibitors of eukaryotic ribosome biogenesis. In their recent Cell paper, they describe the use of these cell-permeable inhibitors to probe the role of the ATPase Midasin. [more]
The 2017 TPCB Student Retreat was held on August 14–15, 2017 at the Mohonk Mountain House. The event featured three-minute thesis presentations, career development talks led by TPCB alumni, and a variety of social activities. The event was organized by TPCB students Ashley Chui, Rachel Leicher, and Linamarie Miller. [more]
TPCB is excited to welcome five new faculty to the program! Prof. Gregory Alushin and Prof. Thomas Walz at Rockefeller, and Prof. Joshua Levitz, Prof. Simon Scheuring, and Prof. Harel Weinstein at Weill Cornell. Together they bring exciting new research opportunities at the forefront of chemical biology. [more]
TPCB congratulates our 2017 graduates, Dr. Angelica Ferguson, Dr. Adam Levinson, and Dr. Carlos Rico. Our newest alumni carried out forefront research in chemical biology, studying ribosome dynamics, natural product total synthesis, and GPCR function, and represent all three institutions in the program. [more]
Recent TPCB graduate Adam Levinson and Prof. Samuel Danishefsky at MSK report the total synthesis of the D-enantiomer of the oncoprotein KRas in a new J. Am. Chem. Soc. paper. This tour de force in chemical synthesis will enable mirror-image yeast display to discover D-peptide ligands for drug development. [more]
Congratulations to Prof. Daniel Bachovchin, who has been named a 2017 Pew-Stewart Scholar! Prof. Bachovchin’s lab at Sloan Kettering uses chemical techniques to study the functions of enzymes that are involved in both normal and pathological processes, with a particular focus on cancer and immune system signaling. [more]
In a new Science paper, TPCB student Malik Chaker-Margot has solved the cryo-EM structure of the small subunit processome, a key intermediate in ribosome assembly. The team in the lab of Prof. Sebastian Klinge at Rockefeller, used this massive structure to gain new insights into the mechanism of eukaryotic ribosome maturation. [more]
TPCB student John Zinder in the lab of Prof. Christopher Lima at MSK has reported a high-resolution crystal structure of the RNA exosome, which is involved in the essential cellular process of RNA degradation. In their Mol. Cell paper, they used alkyne–azide click chemistry was used to create an unnatural RNA substrate probe. [more]
TPCB students Mehtap Isik and Rafal Wiewora have received prestigious fellowships to support their graduate research. Both are third-year students studying computational protein modeling in the lab of Prof. John Chodera at Sloan Kettering. Their research aims to provide powerful new tools to aid drug discovery. [more]
Congratulations to Prof. Christopher Lima, who has been elected a Fellow of the American Academy of Arts and Sciences! Election to the Academy is one of the most significant honors one can receive and recognizes Prof. Lima’s seminal research in RNA processing and protein modification. [more]
TPCB again partnered with the New York Academy of Sciences to present the annual NYAS Chemical Biology Symposium on May 24, 2017 in New York City. The event featured keynote lectures by TPCB faculty member Prof. Sean Brady (Rockefeller) and Prof. Dirk Trauner (NYU) as well as student talks and posters. [more]
Prof. Morgan Huse has received the 2017 Boyer Young Investigator Award for Excellence in Basic Research. This award recognizes outstanding junior faculty at Sloan Kettering. Prof. Huse’s research combines imaging technology, synthetic chemistry, and materials science to understand how immune cells communicate. [more]
Prof. Gregory Alushin has been honored by President Obama with a Presidential Early Career Award in Science and Engineering. This award is the highest honor given by the U.S. government to science and engineering professionals in the early stage of their careers and supports Prof. Alushin’s research into biomechanical forces. [more]
TPCB student Hala Iqbal has developed a metagenomic platform for discovering novel natural products. Working in the lab of Prof. Sean Brady at Rockefeller, she identified a Streptomyces strain an efficient host for heterologous expression of biosynthetic pathways. Their work was recently published in J. Am. Chem. Soc. [more]
Student Profile: TPCB student Chaya Stern describes her non-traditional path to graduate school, where she is now working in Prof. John Chodera’s computational chemistry lab at Sloan Kettering as an NSF Graduate Research Fellow. She also discusses the support she has received from TPCB as a parent. [more]
Prof. Daniel Bachovchin and his lab at Sloan Kettering have used activity-based protein profiling to uncover the mechanism of action of Val-boroPro, a small-molecule that induces persistent tumor immunity in mice. TPCB students Darren Johnson, Eun Bin Go, and Ashley Chui co-authored the work, which was published recently in Nat. Chem. Biol. [more]
Alumni Profile: TPCB alumna Prof. Niroshika Keppetipola discusses her training experience with mentor Prof. Stewart Shuman and how it prepared her for an independent academic career. Now a faculty member at Cal State Fullerton, her lab studies post-translational regulation of RNA binding proteins in alternative splicing. [more]
Congratulations to TPCB alumna Prof. Amrita Hazra, PhD, who has started her independent lab at IISER-Pune as an Assistant Professor of Chemistry & Biology! Prof. Hazra’s lab studies the molecular mechanisms of microbial metabolism. She joins the over 60 TPCB graduates who are using their training to pursue diverse scientific careers. [more]
Faculty Profile: TPCB faculty member Prof. Yael David is a new faculty member at Sloan Kettering. She describe her lab’s approach using protein engineering to study epigenetic regulation and its correlation with disease states. She also discusses her approach to mentoring and her experiences as a woman in science. [more]
Student Profile: TPCB student Malik Chaker-Margot describes his PhD thesis work in which he is using a multidisciplinary approach to study the assembly of the eukaryotic ribosome in Prof. Sebastian Klinge’s lab at Rockefeller. He also discusses his role in organizing the Tri-Institutional Chemical Biology Symposium. [more]
Alumni Profile: TPCB alumna Dr. Amy Grunbeck Perea developed photoactivatable probes to study G protein-coupled receptors with Prof. Tom Sakmar. After graduating with 9 papers on her CV, she did a postdoc fellowship at Genzyme, then joined Abcam, a biotech company in Cambridge, developing new tools for protein analysis. [more]
Faculty Profile: TPCB faculty member Prof. Jue Chen is an HHMI Investigator who studies the structure and function of molecular pumps called ABC transporters that are involved in many important biological processes. She discusses the recent cryo-EM ‘resolution revolution’ and her personalized approach to mentoring her students. [more]