Publications

Student publications at the forefront of chemical biology

TPCB students have an exceptional publication record, averaging over 5 papers per PhD graduate! This prolific group has published over 600 scientific papers since 2003, in high impact journals including Nature, Science, Cell, Journal of the American Chemical Society, ACS Chemical Biology, Biochemistry, Cell Chemical Biology, Nature Chemical Biology, and Proceedings of the National Academy of Sciences. Because of our highly interactive research environment, many of these papers involve multidisciplinary collaborations between TPCB laboratories as well as with other researchers on the Tri-Institutional campuses. In total, TPCB labs have published over 200 papers together!

Name	Publications
Banerjee, Anoosha	Small, G. I.; Fedorova, O.; Olinares, P. D. B.; Chandanani, J.; Banerjee, A.; Choi, Y. J.; Molina, H.; Chait, B. T.; Darst, S. A.; Campbell, E. A. Structural and functional insights into the enzymatic plasticity of the SARS-CoV-2 NiRAN domain. Mol. Cell 2023, 83, 3921-3930.e7. DOI: 10.1016/j.molcel.2023.10.001 PMID: 37890482
Banerjee, Anoosha	Grimes, S. L.; Choi, Y. J.; Banerjee, A.; Small, G.; Anderson-Daniels, J.; Gribble, J.; Pruijssers, A. J.; Agostini, M. L.; Abu-Shmais, A.; Lu, X.; Darst, S. A.; Campbell, E.; Denison, M. R. A mutation in the coronavirus nsp13-helicase impairs enzymatic activity and confers partial remdesivir resistance. mBio 2023, 14, e0106023. DOI: 10.1128/mbio.01060-23 PMID: 37338298
Banerjee, Sourabh	Menon, I.; Huber, T.; Sanyal, S.; Banerjee, S.; Barré, P.; Canis, S.; Warren, J. D.; Hwa, J.; Sakmar, T. P.; Menon, A. K. Opsin is a phospholipid flippase. Curr. Biol. 2011, 21, 149–153. DOI: 10.1016/j.cub.2010.12.031 PMID: 21236677
	Knepp, A. M.; Grunbeck, A.; Banerjee, S.; Sakmar, T. P.; Huber, T. Direct measurement of thermal stability of expressed CCR5 and stabilization by small molecule ligands. Biochemistry 2011, 50, 502–511. DOI: 10.1021/bi101059w PMID: 21155586
	Zaitseva, E.; Saavedra, M.; Banerjee, S.; Sakmar, T. P.; Vogel, R. SEIRA spectroscopy on a membrane receptor monolayer using lipoprotein particles as carriers. Biophys. J. 2010, 99, 2327–2335. DOI: 10.1016/j.bpj.2010.06.054 PMID: 20923668
	Banerjee, S.; Huber, T.; Sakmar, T. P. Rapid incorporation of functional rhodopsin into nanoscale apolipoprotein bound bilayer (NABB) particles. J. Mol. Biol. 2008, 377, 1067–1081. DOI: 10.1016/j.jmb.2008.01.066 PMID: 18313692
Baca, Christian	Baca, C. F.†; Majumder, P.†; Hickling, J. H.; Ye, L.; Teplova, M.; Brady, S. F.; Patel, D. J.; Marraffini, L. A. The CRISPR-associated adenosine deaminase Cad1 converts ATP to ITP to provide antiviral immunity. Cell 2024, 187, 7183–7195. DOI: 10.1016/j.cell.2024.10.002 PMID: 39471810
	Hossain, A. A.; Pigli, Y. Z.; Baca, C. F.; Heissel, S.; Thomas, A.; Libis, V. K.; Burian, J.; Chappie, J. S.; Brady, S. F.; Rice, P. A.; Marraffini, L. A. DNA glycosylases provide antiviral defence in prokaryotes. Nature 2024, 629, 410–416. DOI: 10.1038/s41586-024-07329-9 PMID: 38632404
	Baca, C. F.; Yu, Y.; Rostøl, J. T.; Majumder, P.; Patel, D. J.; Marraffini, L. A. The CRISPR effector Cam1 mediates membrane depolarization for phage defence. Nature 2024, 625, 797–804. DOI: 10.1038/s41586-023-06902-y PMID: 38200316
Banik, Jacob	Charlop-Powers, Z.; Banik, J. J.; Owen, J. G.; Craig, J. W.; Brady, S. F. Selective enrichment of environmental DNA libraries for genes encoding nonribosomal peptides and polyketides by phosphopantetheine transferase-dependent complementation of siderophore biosynthesis. ACS Chem. Biol. 2013, 8, 138–143. DOI: 10.1021/cb3004918 PMID: 23072412
	Bick, M. J.; Banik, J. J.; Darst, S. A.; Brady, S. F. The 2.7 Å resolution structure of the glycopeptide sulfotransferase Teg14. Acta Crystallogr. D Biol. Crystallogr. 2010, 66, 1278–1286. DOI: 10.1107/S0907444910036681 PMID: 21123867
	Banik, J. J.; Craig, J. W.; Calle, P. Y.; Brady, S. F. Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products. J. Am. Chem. Soc. 2010, 132, 15661–15670. DOI: 10.1021/ja105825a PMID: 20945895
	Banik, J. J.; Brady, S. F. Recent application of metagenomic approaches toward the discovery of antimicrobials and other bioactive small molecules. Curr. Opin. Microbiol. 2010, 13, 603–609. DOI: 10.1016/j.mib.2010.08.012 PMID: 20884282
	Bick, M. J.; Banik, J. J.; Darst, S. A.; Brady, S. F. Crystal structures of the glycopeptide sulfotransferase Teg12 in a complex with the teicoplanin aglycone. Biochemistry 2010, 49, 4159–4168. DOI: 10.1021/bi100150v PMID: 20361791
	Banik, J. J.; Brady, S. F. Cloning and characterization of new glycopeptide gene clusters found in an environmental DNA megalibrary. Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 17273–17277. DOI: 10.1073/pnas.0807564105 PMID: 18987322
Bauer, Renato	Wenderski, T. A.; Stratton, C. F.; Bauer, R. A.; Kopp, F.; Tan, D. S. Principal component analysis as a tool for library design: a case study investigating natural products, brand-name drugs, natural product-like libraries, and drug-like libraries. Methods Mol. Biol. 2015, 1263, 225–242. DOI: 10.1007/978-1-4939-2269-7_18 PMID: 25618349
	Bauer, R. A.; Wenderski, T. A.; Tan, D. S. Biomimetic diversity-oriented synthesis of benzannulated medium rings via ring expansion. Nat. Chem. Biol. 2012, 9, 21–29. DOI: 10.1038/nchembio.1130 PMID: 23160003
	Moura-Letts, G.; DiBlasi, C. M.; Bauer, R. A.; Tan, D. S. Solid-phase synthesis and chemical space analysis of a 190-membered alkaloid/terpenoid-like library. Proc. Natl. Acad. Sci. U.S.A. 2011, 108, 6745–6750. DOI: 10.1073/pnas.1015268108 PMID: 21451137
	Bauer, R. A.; DiBlasi, C. M.; Tan, D. S. *The tert-butylsulfinamide lynchpin in transition-metal-mediated multiscaffold library synthesis.* Org. Lett. 2010, 12, 2084–2087. DOI: 10.1021/ol100574y PMID: 20356070
	Bauer, R. A.; Wurst, J. M.; Tan, D. S. Expanding the range of ‘druggable’ targets with natural product-based libraries: an academic perspective. Curr. Opin. Chem. Biol. 2010, 14, 308–314. DOI: 10.1016/j.cbpa.2010.02.001 PMID: 20202892
Berman, Adi	Kelley, M. E.; Berman, A. Y.; Stirling, D. R.; Cimini, B. A.; Han, Y.; Singh, S.; Carpenter, A. E.; Kapoor, T. M.; Way, G. P. High-content microscopy reveals a morphological signature of bortezomib resistance. eLife 2023, 12, e91362. DOI: 10.7554/eLife.91362 PMID: 37753907
Berman, Adi	Berman, A. Y.; Wieczorek, M.; Aher, A.; Olinares, P. D. B.; Chait, B. T.; Kapoor, T. M. A nucleotide binding-independent role for γ-tubulin in microtubule capping and cell division. J. Cell. Biol. 2023, 222, e202204102. DOI: 10.1083/jcb.202204102 PMID: 36695784
Blum, Gil	Chen, S.^†; Wiewiora, R. P.^†; Meng, F.; Babault, N.; Ma, A.; Yu, W.; Qian, K.; Hu, H.; Zou, H.; Wang, J.; Fan, S.; Blum, G.; Pittella-Silva, F.; Beauchamp, K. A.; Tempel, W.; Jiang, H.; Chen, K.; Skene, R. J.; Zheng, Y. G.; Brown, P. J.; Jin, J.; Luo, C.; Chodera, J. D.; Luo, M. The dynamic conformational landscape of the protein methyltransferase SETD8. eLife 2019, 8, e45403. DOI: 10.7554/eLife.45403 PMID: 31081496
	Linscott, J. A.; Kapilashrami, K.; Wang, Z.; Senevirathne, C.; Bothwell, I. R.; Blum, G.; Luo, M. Kinetic isotope effects reveal early transition state of protein lysine methyltransferase SET8. Proc. Natl. Acad. Sci. U.S.A. 2016, 113, E8369-E8378. DOI: 10.1073/pnas.1609032114 PMID: 27940912
	LaFave, L. M.; Béguelin, W.; Koche, R.; Teater, M.; Spitzer, B.; Chramiec, A.; Papalexi, E.; Keller, M. D.; Hricik, T.; Konstantinoff, K.; Micol, J. B.; Durham, B.; Knutson, S. K.; Campbell, J. E.; Blum, G.; Shi, X.; Doud, E. H.; Krivtsov, A. V.; Chung, Y. R.; Khodos, I.; de Stanchina, E.; Ouerfelli, O.; Adusumilli, P. S.; Thomas, P. M.; Kelleher, N. L.; Luo, M.; Keilhack, H.; Abdel-Wahab, O.; Melnick, A.; Armstrong, S. A.; Levine, R. L. Loss of BAP1 function leads to EZH2-dependent transformation. Nat. Med. 2015, 21, 1344–1349. DOI: 10.1038/nm.3947 PMID: 26437366
	Blum, G.; Ibáñez, G.; Rao, X.; Shum, D.; Radu, C.; Djaballah, H.; Rice, J. C.; Luo, M. Small-molecule inhibitors of SETD8 with cellular activity. ACS Chem. Biol. 2014, 9, 2471–2478. DOI: 10.1021/cb500515r PMID: 25137013
	Guo, H.; Wang, R.; Zheng, W.; Chen, Y.; Blum, G.; Deng, H.; Luo, M. Profiling substrates of protein arginine N-methyltransferase 3 with S-adenosyl-L-methionine analogues. ACS Chem. Biol. 2014, 9, 476–484. DOI: 10.1021/cb4008259 PMID: 24320160
	Islam, K.; Chen, Y.; Wu, H.; Bothwell, I. R.; Blum, G. J.; Zeng, H.; Dong, A.; Zheng, W.; Min, J.; Deng, H.; Luo, M. Defining efficient enzyme-cofactor pairs for bioorthogonal profiling of protein methylation. Proc. Natl. Acad. Sci. U.S.A. 2013, 110, 16778–16783. DOI: 10.1073/pnas.1216365110 PMID: 24082136
	Blum, G.; Bothwell, I. R.; Islam, K.; Luo, M. Profiling protein methylation with cofactor analog containing terminal alkyne functionality. Curr. Protoc. Chem. Biol. 2013, 5, 67–88. DOI: 10.1002/9780470559277.ch120241 PMID: 23788324
	Blum, G.; Islam, K.; Luo, M. Bioorthogonal profiling of protein methylation (BPPM) using an azido analog of S-adenosyl-L-methionine. Curr. Protoc. Chem. Biol. 2013, 5, 45–66. DOI: 10.1002/9780470559277.ch120240 PMID: 23667794
	Wang, R.; Islam, K.; Liu, Y.; Zheng, W.; Tang, H.; Lailler, N.; Blum, G.; Deng, H.; Luo, M. Profiling genome-wide chromatin methylation with engineered posttranslation apparatus within living cells. J. Am. Chem. Soc. 2013, 135, 1048–1056. DOI: 10.1021/ja309412s PMID: 23244065
	Zheng, W.; Ibáñez, G.; Wu, H.; Blum, G.; Zeng, H.; Dong, A.; Li, F.; Hajian, T.; Allali-Hassani, A.; Amaya, M. F.; Siarheyeva, A.; Yu, W.; Brown, P. J.; Schapira, M.; Vedadi, M.; Min, J.; Luo, M. Sinefungin derivatives as inhibitors and structure probes of protein lysine methyltransferase SETD2. J. Am. Chem. Soc. 2012, 134, 18004–18014. DOI: 10.1021/ja307060p PMID: 23043551
	Bothwell, I. R.; Islam, K.; Chen, Y.; Zheng, W.; Blum, G.; Deng, H.; Luo, M. Se-adenosyl-L-selenomethionine cofactor analogue as a reporter of protein methylation. J. Am. Chem. Soc. 2012, 134, 14905–14912. DOI: 10.1021/ja304782r PMID: 22917021
	Ibanez, G.; Shum, D.; Blum, G.; Bhinder, B.; Radu, C.; Antczak, C.; Luo, M.; Djaballah, H. A high throughput scintillation proximity imaging assay for protein methyltransferases. Comb. Chem. High Throughput Screen. 2012, 15, 359–371. DOI: 10.2174/138620712800194468 PMID: 22256970
	Wang, R.; Ibáñez, G.; Islam, K.; Zheng, W.; Blum, G.; Sengelaub, C.; Luo, M. Formulating a fluorogenic assay to evaluate S-adenosyl-L-methionine analogues as protein methyltransferase cofactors. Mol. Biosyst. 2011, 7, 2970–2981. DOI: 10.1039/c1mb05230f PMID: 21866297
Bose, Neelanjan	Shinoda, K.; Choe, A.; Hirahara, K.; Kiuchi, M.; Kokubo, K.; Ichikawa, T.; Hoki, J. S.; Suzuki, A. S.; Bose, N.; Appleton, J. A.; Aroian, R. V.; Schroeder, F. C.; Sternberg, P. W.; Nakayama, T. Nematode ascarosides attenuate mammalian type 2 inflammatory responses. Proc Natl Acad Sci U S A 2022, 119, e2108686119. DOI: 10.1073/pnas.2108686119 PMID: 35210367
	Falcke, J. M.^†; Bose, N.^†; Artyukhin, A. B.; Rödelsperger, C.; Markov, G. V.; Yim, J. J.; Grimm, D.; Claassen, M. H.; Panda, O.; Baccile, J. A.; Zhang, Y. K.; Le, H. H.; Jolic, D.; Schroeder, F. C.; Sommer, R. J. Linking genomic and metabolomic natural variation uncovers nematode pheromone biosynthesis. Cell Chem. Biol. 2018, 25, 787–796. DOI: 10.1016/j.chembiol.2018.04.004 PMID: 29779955
	Liu, Z.; Kariya, M. J.; Chute, C. D.; Pribadi, A. K.; Leinwand, S. G.; Tong, A.; Curran, K. P.; Bose, N.; Schroeder, F. C.; Srinivasan, J.; Chalasani, S. H. *Predator-secreted sulfolipids induce defensive responses in C. elegans.* Nat. Commun. 2018, 9, 1128. DOI: 10.1038/s41467-018-03333-6 PMID: 29555902
	Narayan, A.; Venkatachalam, V.; Durak, O.; Reilly, D. K.; Bose, N.; Schroeder, F. C.; Samuel, A. D.; Srinivasan, J.; Sternberg, P. W. *Contrasting responses within a single neuron class enable sex-specific attraction in Caenorhabditis elegans.* Proc. Natl. Acad. Sci. U.S.A. 2016, 113, E1392–E1401. DOI: 10.1073/pnas.1600786113 PMID: 26903633
	Chaudhuri, J.; Bose, N.; Tandonnet, S.; Adams, S.; Zuco, G.; Kache, V.; Parihar, M.; von Reuss, S. H.; Schroeder, F. C.; Pires-daSilva, A. Mating dynamics in a nematode with three sexes and its evolutionary implications. Sci. Rep. 2015, 5, 17676. DOI: 10.1038/srep17676 PMID: 26631423
	Yim, J. J.; Bose, N.; Meyer, J. M.; Sommer, R. J.; Schroeder, F. C. Nematode signaling molecules derived from multimodular assembly of primary metabolic building blocks. Org. Lett. 2015, 17, 1648–1651. DOI: 10.1021/acs.orglett.5b00329 PMID: 25782998
	Zugasti, O.; Bose, N.; Squiban, B.; Belougne, J.; Kurz, C. L.; Schroeder, F. C.; Pujol, N.; Ewbank, J. J. *Activation of a G protein-coupled receptor by its endogenous ligand triggers the innate immune response of Caenorhabditis elegans.* Nat. Immunol. 2014, 15, 833–838. DOI: 10.1038/ni.2957 PMID: 25086774
	Bose, N.; Meyer, J. M.; Yim, J. J.; Mayer, M. G.; Markov, G. V.; Ogawa, A.; Schroeder, F. C.; Sommer, R. J. Natural variation in dauer pheromone production and sensing supports intraspecific competition in nematodes. Curr. Biol. 2014, 24, 1536–1541. DOI: 10.1016/j.cub.2014.05.045 PMID: 24980503
	Mahanti, P.; Bose, N.; Bethke, A.; Judkins, J. C.; Wollam, J.; Dumas, K. J.; Zimmerman, A. M.; Campbell, S. L.; Hu, P. J.; Antebi, A.; Schroeder, F. C. *Comparative metabolomics reveals endogenous ligands of DAF-12, a nuclear hormone receptor, regulating C. elegans* development and lifespan.** Cell Metab. 2014, 19, 73–83. DOI: 10.1016/j.cmet.2013.11.024 PMID: 24411940
	Artyukhin, A. B.; Yim, J. J.; Srinivasan, J.; Izrayelit, Y.; Bose, N.; von Reuss, S. H.; Jo, Y.; Jordan, J. M.; Baugh, L. R.; Cheong, M.; Sternberg, P. W.; Avery, L.; Schroeder, F. C. *Succinylated octopamine ascarosides and a new pathway of biogenic amine metabolism in Caenorhabditis elegans.* J. Biol. Chem. 2013, 288, 18778–18783. DOI: 10.1074/jbc.C113.477000 PMID: 23689506
	Izrayelit, Y.; Robinette, S. L.; Bose, N.; von Reuss, S. H.; Schroeder, F. C. *2D NMR-based metabolomics uncovers interactions between conserved biochemical pathways in the model organism Caenorhabditis elegans.* ACS Chem. Biol. 2013, 8, 314–319. DOI: 10.1021/cb3004644 PMID: 23163760
	Bose, N.; Ogawa, A.; von Reuss, S. H.; Yim, J. J.; Ragsdale, E. J.; Sommer, R. J.; Schroeder, F. C. Complex small-molecule architectures regulate phenotypic plasticity in a nematode. Angew. Chem. Int. Ed. Engl. 2012, 51, 12438–12443. DOI: 10.1002/anie.201206797 PMID: 23161728
	Srinivasan, J.; von Reuss, S. H.; Bose, N.; Zaslaver, A.; Mahanti, P.; Ho, M. C.; O’Doherty, O. G.; Edison, A. S.; Sternberg, P. W.; Schroeder, F. C. *A modular library of small molecule signals regulates social behaviors in Caenorhabditis elegans.* PLoS Biol. 2012, 10, e1001237. DOI: 10.1371/journal.pbio.1001237 PMID: 22253572
	von Reuss, S. H.; Bose, N.; Srinivasan, J.; Yim, J. J.; Judkins, J. C.; Sternberg, P. W.; Schroeder, F. C. *Comparative metabolomics reveals biogenesis of ascarosides, a modular library of small-molecule signals in C. elegans.* J. Am. Chem. Soc. 2012, 134, 1817–1824. DOI: 10.1021/ja210202y PMID: 22239548
Bothwell, Ian	Shu, X.; Dai, Q.; Wu, T.; Bothwell, I. R.; Yue, Y.; Zhang, Z.; Cao, J.; Fei, Q.; Luo, M.; He, C.; Liu, J. N⁶-Allyladenosine: A new small molecule for RNA labeling identified by mutation assay. J. Am. Chem. Soc. 2017, 139, 17213–17216. DOI: 10.1021/jacs.7b06837 PMID: 29116772
	Linscott, J. A.; Kapilashrami, K.; Wang, Z.; Senevirathne, C.; Bothwell, I. R.; Blum, G.; Luo, M. Kinetic isotope effects reveal early transition state of protein lysine methyltransferase SET8. Proc. Natl. Acad. Sci. U.S.A. 2016, 113, E8369-E8378. DOI: 10.1073/pnas.1609032114 PMID: 27940912
	Bothwell, I. R.; Luo, M. Large-scale, protection-free synthesis of Se-adenosyl-L-selenomethionine analogues and their application as cofactor surrogates of methyltransferases. Org. Lett. 2014, 16, 3056–3059. DOI: 10.1021/ol501169y PMID: 24852128
	Islam, K.; Chen, Y.; Wu, H.; Bothwell, I. R.; Blum, G. J.; Zeng, H.; Dong, A.; Zheng, W.; Min, J.; Deng, H.; Luo, M. Defining efficient enzyme-cofactor pairs for bioorthogonal profiling of protein methylation. Proc. Natl. Acad. Sci. U.S.A. 2013, 110, 16778–16783. DOI: 10.1073/pnas.1216365110 PMID: 24082136
	Winter, J. M.; Chiou, G.; Bothwell, I. R.; Xu, W.; Garg, N. K.; Luo, M.; Tang, Y. Expanding the structural diversity of polyketides by exploring the cofactor tolerance of an inline methyltransferase domain. Org. Lett. 2013, 15, 3774–3777. DOI: 10.1021/ol401723h PMID: 23837609
	Blum, G.; Bothwell, I. R.; Islam, K.; Luo, M. Profiling protein methylation with cofactor analog containing terminal alkyne functionality. Curr. Protoc. Chem. Biol. 2013, 5, 67–88. DOI: 10.1002/9780470559277.ch120241 PMID: 23788324
	Bothwell, I. R.; Islam, K.; Chen, Y.; Zheng, W.; Blum, G.; Deng, H.; Luo, M. Se-adenosyl-L-selenomethionine cofactor analogue as a reporter of protein methylation. J. Am. Chem. Soc. 2012, 134, 14905–14912. DOI: 10.1021/ja304782r PMID: 22917021
	Islam, K.; Bothwell, I.; Chen, Y.; Sengelaub, C.; Wang, R.; Deng, H.; Luo, M. Bioorthogonal profiling of protein methylation using azido derivative of S-adenosyl-L-methionine. J. Am. Chem. Soc. 2012, 134, 5909–5915. DOI: 10.1021/ja2118333 PMID: 22404544
Burdette, Colin	Saca, V. R.; Burdette, C.; Sakmar, T. P. GPCR biosensors to study conformational dynamics and signaling in drug discovery. Annu. Rev. Pharmacol. Toxicol. 2024, in press. DOI: 10.1146/annurev-pharmtox-061724-080836 PMID: 39298797
Burnside, Chloe	Harper, N. J.†; Burnside, C.†; Klinge, S. Principles of mitoribosomal small subunit assembly in eukaryotes. Nature 2023, 614, 175–181. DOI: 10.1038/s41586-022-05621-0 PMID: 36482135
Cahir, Clare	Yang, L.; Han, Y.; Zhou, T.; Lacko, L. A.; Saeed, M.; Tan, C.; Danziger, R.; Zhu, J.; Zhao, Z.; Cahir, C.; Giana, A. M.; Li, Y.; Dong, X.; Moroziewicz, D.; NYSCF Global Stem Cell Array® Team; Paull, D.; Chen, Z.; Zhong, A.; Noggle, S. A.; Rice, C. M.; Qi, Q.; Evans, T.; Chen, S. Isogenic human trophectoderm cells demonstrate the role of NDUFA4 and associated variants in ZIKV infection. iScience 2023, 26, 107001. DOI: 10.1016/j.isci.2023.107001 PMID: 37534130
Cahir, Clare	Han, Y.; Tan, L.; Zhou, T.; Yang, L.; Carrau, L.; Lacko, L. A.; Saeed, M.; Jiajun, Z.; Zhao, Z.; Nilsson-Payant, B. E.; Tenorio Lira Neto, F.; Cahir, C.; Giana, A. M.; Chai, J. C.; Li, Y.; Dong, X.; Moroziewicz, D.; NYSCF Global Stem Cell Array Team; Paull, D; Zhang, T.; Koo, S.; Tan, C.; Danziger, R.; Ba, Q.; Feng, L; Chen, Z.; Zhong, A.; Wise, G. J.; Xiang, J. Z.; Wang, H.; Schwartz, R. E.; tenOever, B. R.; Noggle, S. A.; Rice, C. M.; Qi, Q.; Evans, T.; Chen, S. A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants. Cell Stem Cell 2022, 29, 1475-1490. DOI: 10.1016/j.stem.2022.09.008 PMID: 36206731
Carl, Ayala	Reynolds, M. J.; Hachicho, C.; Carl, A. G.; Gong, R.; Alushin, G. M. Bending forces and nucleotide state jointly regulate F-actin structure. Nature 2022, 611, 380–386. DOI: 10.1038/s41586-022-05366-w PMID: 36289330
Carl, Ayala	Uson, M. L.; Carl, A.; Goldgur, Y.; Shuman, S. *Crystal structure and mutational analysis of Mycobacterium smegmatis* FenA highlight active site amino acids and three metal ions essential for flap endonuclease and 5′ exonuclease activities.** Nucleic Acids Res. 2018, 46, 4164–4175. DOI: 10.1093/nar/gky238 PMID: 29635474
Chaker-Margot, Malik	Singh, S.; Vanden Broeck, A.; Miller, L.; Chaker-Margot, M.; Klinge, S. Nucleolar maturation of the human small subunit processome. Science 2021, 373, eabj5338. DOI: 10.1126/science.abj5338 PMID: 34516797
	Chaker-Margot, M.; Klinge, S. Assembly and early maturation of large subunit precursors. RNA 2019, 25, 465–471. DOI: 10.1261/rna.069799.118 PMID: 30670483
	Bolze, A.; Boisson, B.; Bosch, B.; Antipenko, A.; Bouaziz, M.; Sackstein, P.; Chaker-Margot, M.; Barlogis, V.; Briggs, T.; Colino, E.; Elmore, A. C.; Fischer, A.; Genel, F.; Hewlett, A.; Jedidi, M.; Kelecic, J.; Krüger, R.; Ku, C. L.; Kumararatne, D.; Lefevre-Utile, A.; Loughlin, S.; Mahlaoui, N.; Markus, S.; Garcia, J. M.; Nizon, M.; Oleastro, M.; Pac, M.; Picard, C.; Pollard, A. J.; Rodriguez-Gallego, C.; Thomas, C.; Von Bernuth, H.; Worth, A.; Meyts, I.; Risolino, M.; Selleri, L.; Puel, A.; Klinge, S.; Abel, L.; Casanova, J. L. Incomplete penetrance for isolated congenital asplenia in humans with mutations in translated and untranslated RPSA exons. Proc. Natl. Acad. Sci. U.S.A. 2018, 115, E8007–E8016. DOI: 10.1073/pnas.1805437115 PMID: 30072435
	Chaker-Margot, M.* Assembly of the small ribosomal subunit in yeast: Mechanism and regulation. RNA 2018, 24, 881–891. DOI: 10.1261/rna.066985.118 PMID: 29712726
	Sanghai, Z. A.^†; Miller, L.^†; Molloy, K. R.; Barandun, J.; Hunziker, M.; Chaker-Margot, M.; Wang, J.; Chait, B. T.; Klinge, S. Modular assembly of the nucleolar pre-60S ribosomal subunit. Nature 2018, 556, 126–129. DOI: 10.1038/nature26156 PMID: 29512650
	Barandun, J.^†; Chaker-Margot, M.^†; Hunziker, M.; Molloy, K. R.; Chait, B. T.; Klinge, S. The complete structure of the small-subunit processome. Nat. Struct. Mol. Biol. 2017, 24, 944–953. DOI: 10.1038/nsmb.3472 PMID: 28945246
	Chaker-Margot, M.; Barandun, J.; Hunziker, M.; Klinge, S. Architecture of the yeast small subunit processome. Science 2017, 355, eaal1880. DOI: 10.1126/science.aal1880 PMID: 27980088
	Hunziker, M.; Barandun, J.; Petfalski, E.; Tan, D.; Delan-Forino, C.; Molloy, K. R.; Kim, K. H.; Dunn-Davies, H.; Shi, Y.; Chaker-Margot, M.; Chait, B. T.; Walz, T.; Tollervey, D.; Klinge, S. UtpA and UtpB chaperone nascent pre-ribosomal RNA and U3 snoRNA to initiate eukaryotic ribosome assembly. Nat. Commun. 2016, 7, 12090. DOI: 10.1038/ncomms12090 PMID: 27354316
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