TPCB Faculty
Xuejun Jiang, PhD
Memorial Sloan Kettering Cancer Center
Education
PhD, University of Texas Southwestern Medical Center at Dallas
MA, Fudan University, Shanghai
BS, Fudan University, Shanghai
Research Topics
- Bioactive Small Molecules
- High-throughput screening assays
- Chemical probe development
- Rational drug design
- Macromolecular Structure and Function
- Enzymology
- Mass spectrometry
- Chemical Cell Biology
- Chemical genetics
- Proteomics
- Metabolomics
Therapeutic Areas
- Cancer
- Cardiovascular
- Neuroscience
Research in the Jiang lab focuses on three intertwined directions highly relevant to human disease: (1) the molecular basis of programmed cell death, including apoptosis and a newly defined death mode known as ferroptosis; (2) the molecular basis of autophagy; and (3) regulation of the tumor suppressor PTEN, which is also a modulator for both cell death and autophagy. We also aim to translate our basic research finding into potential therapeutic approaches. The laboratory utilizes a combination of approaches including biochemistry, chemical biology, proteomics, molecular cell biology, high-throughput screening, three-dimensional microfluidic cell array, and mouse modeling.
Read more about Prof. Jiang’s research on the Sloan Kettering website