TPCB Faculty
Minkui Luo, PhD
Memorial Sloan Kettering Cancer Center
Education
PhD, 2005, Princeton University
BA, 1999, Fudan University
Awards
NIH Director’s New Innovator Awardee
Research Topics
- Bioactive Small Molecules
- High-throughput screening assays
- Chemical probe development
- Macromolecular Structure and Function
- Enzymology
- Chemical Cell Biology
- Chemical genetics
- Proteomics
- Activity-based protein profiling
- Biotechnology
- Protein engineering
Therapeutic Areas
- Cancer
- Neuroscience
The projects in the Luo lab aim to provide new chemical genetic tools to define, perturb and manipulate essential functions of the enzymes involving protein posttranslational modification (methyltransferases and acetyltransferases). Another focus is to design and synthesize tight-binding inhibitors as anti-cancer drug candidates by blocking these protein-modifying activities. Researchers in the fields of chemistry, biology and biochemistry work together closely to synthesize novel chemical reagents, elucidate illness-causing mechanisms at molecular level and develop potential treatments for human diseases.
Read more about Prof. Luo’s research on the Sloan Kettering website