TPCB Faculty

Jochen Buck, MD, PhD

Weill Cornell Medical College

jobuck@med.cornell.edu

Education

MD, 1984, University of Tubingen

PhD, 1985, University of Tubingen

Research Topics

Bioactive Small Molecules
- Rational drug design
- High-throughput screening assays
Macromolecular Structure and Function
- Enzymology
Chemical Cell Biology
- Proteomics
- Metabolomics

Therapeutic Areas

Cancer
Cardiovascular
Diabetes
Microbiology

The second messenger molecule cAMP, which modulates cell growth and differentiation in organisms from bacteria to higher eukaryotes, is produced by adenylyl cyclases. Mammals possess two distinct classes of adenylyl cyclase, the hormone-responsive, transmembrane adenylyl cyclases (tmAC) and the bicarbonate-regulated Soluble Adenylyl Cyclase (sAC). sAC, which the Buck lab purified and cloned in collaboration with Dr. Lonny Levin’s lab, and tmACs define distinct cAMP signaling pathways within eukaryotic cells.

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