TPCB Faculty
Arvin Dar, PhD
Memorial Sloan Kettering Cancer Center
Education
PhD, 2006, University of Toronto
BS, 1999, University of Western Ontario
Research Topics
- Bioactive Small Molecules
- Rational drug design
- Chemical probe development
- Macromolecular Structure and Function
- Enzymology
- X-ray crystallography
- Mass spectrometry
- Chemical Cell Biology
- Chemical genetics
- Proteomics
- Activity-basd protein profiling
Therapeutic Areas
- Cancer
- Immunology
The Dar lab explores cancer mechanisms and new paradigms in drug discovery through the integration of genetics, biochemistry, structure, and small molecule discovery. Our goals are to better understand normal and disease mechanisms and to discover effective chemical approaches to rewire signal transduction pathways for therapeutic applications. We are currently focused on developing small molecule stabilizers, degraders, molecular glues, and conformational modulators toward several classes of targets, including against mutated cancer drivers, pseudokinases, phosphatases, and transcription factor complexes.
Read more about Prof. Dar’s research on the Sloan Kettering website