TPCB Faculty
Lewis Cantley, PhD
Weill Cornell Medical College
Education
PhD, 1975, Cornell University
BS, 1971, West Virginia Wesleyan College
Awards
2013 Breakthrough Prize in Life Sciences
Member, National Academy of Science
Research Topics
- Bioactive Small Molecules
- High-throughput screening assays
- Macromolecular Structure and Function
- Enzymology
- Mass spectrometry
- Chemical Cell Biology
- Proteomics
- Metabolomics
Therapeutic Areas
- Cancer
- Diabetes
The Cantley lab utilizes genetically engineered mouse models and human cancer cell lines to understand the biochemical pathways by which oncogenes such as EGFR, PI3K, RAS and others mediate changes in cell metabolism, cell growth and cell transformation. A variety of approaches are being used to characterize these pathways, including inducible shRNA, mass spec proteomics and RNASeq. In addition, we are utilizing mass spec metabolomics to monitor the effect of inhibitors of these oncoproteins on the flux of metabolites in cancer cell lines and in tumors. These studies are revealing metabolic enzymes that could be targeted for treating cancers.
Read more about Prof. Cantley’s research on the Weill Cornell website