TPCB Faculty
Anthony Sauve, PhD
Weill Cornell Medical College
Education
PhD, 1997, Princeton University
BA, 1986, University of California, Berkeley
Research Topics
- Bioactive Small Molecules
- Chemical methodology
- Rational drug design
- Chemical probe development
- Macromolecular Structure and Function
- Enzymology
- Chemical Cell Biology
- Chemical genetics
-
Therapeutic Areas
- Cancer
TPCB is sad to announce the passing of Prof. Anthony A. Sauve on Sep 29, 2022. Anthony was a brilliant scientist, a wonderful colleague, and a dedicated educator who made innumerable contributions to the TPCB graduate program. He will be sorely missed. We extend our deepest condolences to his family and friends.
ADP-ribosyl-transferases participate in signaling pathways in bacteria, yeast, plants and humans and use NAD as a non-redox electrophile to accomplish post-translational modification of proteins or second messenger formation. Work in the Sauve lab explores 1. the biochemical principles of NAD activation, biochemical reaction mechanisms, and the regulation of enzyme activity, 2. the design and synthesis of small molecules that can either activate or inhibit these enzymes and the development of small molecule tools for the study of these enzymes in vivo.
Read more about Prof. Sauve’s research on the Weill Cornell website