PhD, 1997, Princeton University
BA, 1986, University of California, Berkeley
ADP-ribosyl-transferases participate in signaling pathways in bacteria, yeast, plants and humans and use NAD as a non-redox electrophile to accomplish post-translational modification of proteins or second messenger formation. Work in the Sauve lab explores 1. the biochemical principles of NAD activation, biochemical reaction mechanisms, and the regulation of enzyme activity, 2. the design and synthesis of small molecules that can either activate or inhibit these enzymes and the development of small molecule tools for the study of these enzymes in vivo.
Read more about Prof. Sauve’s research on the Weill Cornell website